Journal List > J Korean Ophthalmol Soc > v.49(4) > 1008236

Yoon, Lee, and Nam: Macular Thickness in Healthy Korean Eyes Using OCT3 Comparing with Normative Data

Abstract

Purpose

To determine whether there are significant differences between the retinal thicknesses of the macular area in eyes of healthy Koreans compared with normative data using OCT3 (version 4.0).

Methods

The study was performed in 111 eyes of 71 adults between the ages of 20 and 69 with corrected vision of 0.8 or greater and no systemic or ocular disease. The subject group was designed to have a similar age distribution to that of normative data. An OCT3 fast macular map was used to measure macular thickness. The results were further analyzed and compared with the normative data.

Results

The overall results from the subject group were similar to the normative data. However, the nasal parts of the outer ring were thicker than the normative data and the temporal parts of the outer ring were thinner (p<.0001). When each age group was compared, the thickness of the superior part of the inner ring and the nasal part of the inner and outer rings were thicker than the normative data in the age groups of twenties and thirties (p<.05). For the nasal parts of outer ring, the macula were thicker by OCT examination than the normative data in 25.2% of subjects, although they were clinically normal.

Conclusions

Macular thickness in healthy Koreans was generally similar to the normative data of OCT3. However, a slight difference may exist and must be considered when measuring and interpreting macular thickness measurements.

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Figure 1.
Sample OCT3 display of diabetic macular edema patient with normative data. It displays the macular normative database information in the form of clinically useful fast macular map and chart. Colored bands demonstrate the normal distribution of macular thickness measurements.
jkos-49-601f1.tif
Figure 2.
An analysis of the spread of macular thickness by OCT3 normative data in healthy Korean. At first the population was divided in age categories, and then five sub‐ groups were made according to color‐ code of the normative data. Color-code of the normative data was divided in following percentile categories: more than 99% as very thick, 95∼99% as thick, 5∼95% as normal, 1∼ 5% as thin, and less than 1% as very thin. Number of eyes was presented in each macular area of each sub-group. Some cases represented abnormal, even though patients' macula was normal clinically. * 1 mm=1 mm central ring; 3=3 mm inner ring; 6=6 mm outer ring; § tem=temporal; ∏ sup=superior; # nas=nasal; ** inf=inferior.
jkos-49-601f2.tif
Figure 3.
Comparison of healthy Korean macular thickness among the age groups.
jkos-49-601f3.tif
Figure 4.
Comparison of healthy Korean macular thickness between male and female. * 1 mm=1 mm central ring; 3=3 mm inner ring; 6=6 mm outer ring; § tem=temporal; ∏ sup=superior; # nas=nasal; ** inf=inferior.
jkos-49-601f4.tif
Table 1.
Subject distribution by age
Age (y) Present study Normative data
20∼29 27 eyes (24%) 58 eyes (18%)
30∼39 20 eyes (18%) 45 eyes (14%)
40∼49 25 eyes (23%) 74 eyes (23%)
50∼59 22 eyes (20%) 71 eyes (21%)
60∼ 17 eyes (15%) 80 eyes (24%)
Average age (y) 44±13.8 47±15.8

Test of homogeneity: p-value=0.18.

Table 2.
Comparison between macular thickness of healthy Korean and normative data of OCT3
Present data (µm) Normative data (µm) p-value
Central ring 198.7±16.5 203.5±21.5 .0818
Inner ring Superior 277.1±16.1 269.5±16.1 .0579
Inferior 265.3±19.2 271.5±15.5 .0981
Nasal 276.3±16.2 268.5±17.3 .0622
Temporal 261.5±15.3 267.0±16.4 .1054
Mean 270.0±15.0 269.1±15.2 .5412
Outer ring Superior 240.4±13.2 231.5±14.8 .0746
Inferior 237.9±14.9 231.5±14.8 .2823
Nasal 264.7±13.9 236.0±23.0 <.0001*
Temporal 224.6±13.0 237.5±23.3 <.0001*
Mean 241.9±12.2 233.8±14.5 .0612

* Statistical significance was calculated by goodness of fit test (p<.05).

Table 3.
Macular thickness measurements in healthy eyes reported in previous studies using OCT
Source No. of eyes studied Type of OCT device Protocol No. of scans Macular Thickness (1 mm diameter)
Hee et al, 199817 73 Prototype 6 174±18 µm
Massin et al, 200220 60 Commercial 6 170±18 µm
Paunescu et al, 200421 10 OCT3 6 202±20 µm
Chan et al, 200623 37 OCT3 6 212±20 µm
Present study 111 OCT3 6 198±16.5 µm
Table 4.
Macular thickness measurements in healthy korean eyes reported in previous studies using OCT
Source No. of eyes studied Type of OCT device Protocol No. of scans Macular Thickness (1 mm diameter)
Kang et al, 200422 112 OCT3 6 208±18 µm
Jung et al, 200413 120 OCT3 6 193.4±14.6 µm
Lee et al, 200514 104 OCT3 6 190.5±13.9 µm
Present study 111 OCT3 6 198.7±16.5 µm
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