Two Cases of Topiramate-induced Acute Myopia

Wook Kim Seong; Gwan Seo Seong; Her Jun; Soo Ahn Ki; Jun Choi Bong

doi:10.3341/jkos.2008.49.6.1033

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Seong, Seong, Jun, Ki, and Bong: Two Cases of Topiramate-induced Acute Myopia

Original Article

J Korean Ophthalmol Soc 2008;49(6):1033-1040.

Published online: 8 September 2008

DOI: https://doi.org/10.3341/jkos.2008.49.6.1033

Two Cases of Topiramate-induced Acute Myopia

Wook Kim Seong, M.D.¹, Gwan Seo Seong, M.D.^1,, Her Jun, M.D.¹, Soo Ahn Ki, M.D.², Jun Choi Bong, M.D.²

¹Department of Ophthalmology Pusan Paik Hospital Inje University Pusan, Korea

¹Lee Eye Hospital Pusan, Korea

Address reprint requests to Seong Gwan Seo, M.D. Department of Ophthalmology, Inje University Pusan Paik Hospital #633-165 Geageum-dong, Pusanjin-gu, Pusan 614-735, Korea Tel: 82-51-890-6016, Fax: 82-51-890-6329, E-mail: seossg@hanmail.net

26 February 2008 Accepted 11 September 2007

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We describe 2 cases of bilateral acute myopia associated with topiramate, a drug that has recently been prescribed for epilepsy or weight reduction.

Case summary

A 24-year-old woman and a 25-year-old woman, both previously devoid of ocular problems, visited our hospital with blurry vision after taking topiramate for weight reduction. A thorough medical history review and ocular examinations, including a slit lamp examination, were performed.

Conclusions

Slit-lamp examinations revealed forward displacement of the lens-iris diaphragm, which resulted in myopia and anterior chamber shallowing. Discontinuation of topiramate and the administration of cycloplegic agents successfully resolved the symptoms.

Keywords: Acute myopia, Cycloplegic agent, Topiramate

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Figure 1.

(Case 1) Note shallow anterior chamber (3 corneal thickness deep centrally) at initial presentation. (A) and (B) the right eye; (C) and (D) the left eye.

Figure 2.

(Case 1) Her anterior chamber deepened (6 corneal thickness deep centrally) with cycloplegics after cessation of topiramate. (A) and (B) the right eye; (C) and (D) the left eye.