Menetrier's Disease Accompanied with Adenocarcinoma

Tae Il Kim

doi:10.4166/kjg.2009.53.5.271

Journal List > Korean J Gastroenterol > v.53(5) > 1006542

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kim: Menetrier's Disease Accompanied with Adenocarcinoma

Image of the Month

Korean J Gastroenterol 2009;53(5):271-274.

Published online: 21 February 2009

DOI: https://doi.org/10.4166/kjg.2009.53.5.271

Menetrier's Disease Accompanied with Adenocarcinoma

Tae Il Kim, M.D.

Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea

Correspondence to: Tae Il Kim, M.D. Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134, Shinchon-dong, Seodaemun-gu, Seoul 120-752, Korea Tel: +82-2-2228-1965, Fax: +82-2-393-6884 E-mail: taeilkim@yuhs.ac

REFERENCES

1. Eisenstat DD, Griffiths AM, Cutz E, Petric M, Drumm B. Acute cytomegalovirus infection in a child with Menetrier's disease. Gastroenterology. 1995; 109:592–595.

2. Lee KH, Lee NR, Kwak JY, Yim CY, Lee SO. A case of improved Menetrier's disease after the eradication of the Helicobacter pylori and long term treatment with proton pump inhibitor. Korean J Gastrointest Endosc. 2004; 28:29–33.

3. Madsen LG, Taskiran M, Madsen JL, Bytzer P. Menetrier's disease and Helicobacter pylori: normalization of gastrointestinal protein loss after eradication therapy. Dig Dis Sci. 1999; 44:2307–2312.

4. Dempsey PJ, Goldenring JR, Soroka CJ, et al. Possible role of transforming growth factor alpha in the pathogenesis of Menetrier's disease: supportive evidence from human & trans-genic mice. Gastroenterology. 1992; 103:1950–1963.

5. Burdick JS, Chung E, Tanner G, et al. Treatment of Mé né tri-er's disease with a monoclonal antibody against the epidermal growth factor receptor. N Engl J Med. 2000; 343:1697–1701.

6. Lim YJ, Lee PR, Kim YH, et al. Clinical features of Menetrier's disease in Korea: a report of 16 cases. Korean J Gastrointest Endosc. 2000; 21:909–916.

7. Citrin Y, Sterling K, Halsted JA. The mechanism of hypo-proteinemia associated with giant hypertrophy of the gastric mucosa. N Engl J Med. 1957; 257:906.

8. Jouini M, Ksontini R, Kacem MJ, et al. Menetrier's disease associated with a gastric adenocarcinoma. Ann Gastroenterol Hepatol. 1996; 31:341–346.

9. Scharschmidt BF. The natural history of hypertrophic gastropathy (Menetrier's disease). Report of a case with 16 year follow-up and review of 120 cases from the literature. Am J Med. 1977; 63:644–652.

10. Lim KC, Kim YJ, Lee SA, et al. A case of Menetrier's disease associated with two adenomatous polyps. Korean J Gastroenterol. 1999; 33:282–286.

11. Wood GM, Bates C, Brown RC, Losowsky MS. Intramucosal carcinoma of the gastric antrum complicating Menetrier's disease. J Clin Pathol. 1983; 36:1071–1075.

Fig. 1.

The findings of gastroscopy and endoscopic ultrasonography (EUS). (A, B) Gastroscopy showed diffuse thickening of gastric mucosal folds with polypoid lesions in body without significant changes in antrum. (C) The fold hypertrophy was confined to mucosa layer on EUS. (D) After 1 year, gastroscopy showed more prominently thickening some irregular mucosal changes in upper body.

Fig. 2.

Abdomen-pelvis CT scans showed thickening of gastric mucosa and the evidence of mucosal swelling.

Fig. 3.

Histopathologic findings. (A) After total gastrectomy, specimen showed diffuse thickening of gastric mucosal folds with polypoid lesions in body. Some prominent mucosal irregularity is seen in upper body (arrow). (B) Gastric mucosa showed diffuse foveolar hyper-plasia and (C) tubulovillous adenoma with low grade epithelial dysplasia (H&E stain, ×100). (D) Arrowed area in (A) showed well-differentiated adenocarcinoma confined to mucosa (H&E stain, ×100).

TOOLS

Similar articles