A Case of Dermatomyositis Associated with Prostate Cancer

Hee Yeon Kim; Seung-Ki Kwok; Wan-Uk Kim

doi:10.4078/jkra.2009.16.1.59

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Kim, Kwok, and Kim: A Case of Dermatomyositis Associated with Prostate Cancer

Original Article

J Korean Rheum Assoc 2009;16(1):59-63.

Published online: 20 March 2009

DOI: https://doi.org/10.4078/jkra.2009.16.1.59

A Case of Dermatomyositis Associated with Prostate Cancer

Hee Yeon Kim, Seung-Ki Kwok, Wan-Uk Kim

Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, Korea

Received 16 January 2009 Accepted 24 February 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dermatomyositis is an idiopathic inflammatory myopathy with characteristic cutaneous lesions and progressive symmetric proximal muscle weakness. An association between dermatomyositis and malignancy has long been reported on. A 73 year-old male patient with had biopsy-proven prostate cancer presented with typical skin lesions and proximal muscle weakness. On the laboratory findings, the muscle enzymes were prominently elevated. EMG and muscle biopsy showed typical findings that were consistent with dermatomyositis. The patient was successfully treated with systemic steroid, intravenous immunoglobulin and methotrexate. In Korea, dermatomyositis is frequently complicated by stomach, lung and breast cancers. To the best of our knowledge, this is the first Korean report of dermatomyositis accompanied by prostate cancer. Here, we describe the case of dermatomyositis with prostate cancer and we briefly review the relevant literatures.

Keywords: Dermatomyositis, Prostate cancer, Malignancy

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Fig. 1.

(A) Malar erythema involving the nasolabial fold and erythematous poikiloderma on the upper chest (the “V” sign). (B) Pruritic erythematous poikiloderma on the upper back (the shawl sign).

Fig. 2.

Histology of the skeletal muscle from the gluteus medius muscle shows perivascular (arrow) and interfascicular lymphohistiocyte infiltrations with polymorphonuclear leukocytes, and these findings are suggestive of inflammatory myopathy (H&E stain, ×200).

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