Journal List > J Korean Rheum Assoc > v.14(3) > 1003573

Jung, Shin, and Min: Remediable Hyperglycemia in a Patient with Weber-Christian Disease

Abstract

Weber-Christian disease (WCD) is an inflammatory disease of subcutaneous fat tissue which is characterized by relapsing, febrile tender nodules and histologically lobular panniculitis. Any area of the body containing fat can be affected by WCD. Several cases of WCD have been reported as involvement of the heart, lung, liver and kidney. Acute illness (ex. acute myocardiac infarction, infection, etc) can be complicated with stress-related hyperglycemia and increase insulin restistance. Finally this case show that Weber-Christian disease accompanied by marked hyperglycemia and insulin resistance, which resolved soon after corticosteroid.

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Fig. 1.
Multiple nodular lesions with tenderness on anterior side of left leg and right ankle (arrow).
jkra-14-279f1.tif
Fig. 2.
The diffusely scattered fat degenerated lesions are observed at low-power field (∗100) and infiltration of lymphocyties, neutrophils and histiocytes is found at high-power field (∗400).
jkra-14-279f2.tif
Table 1.
The serial results of laboratory examinations
HD#1 HD#5 HD#8 HD#15 OPD#26
Blood sugar (mg/dL) 289 (PC) 119 (AC) 94 (AC) 88 (AC)
Insulin (g/dL) 11.92 11.24 4.75
HOMA IR Index 3.50 1.03
HbA1c (%) 7.1 6.0
Urinalysis glucose 4+ -
AST (U/L) 51 61 103 17 21
ALT (U/L) 30 113 139 52 30
Υ-GPT (U/L) 36 67 60 31
ESR (mm/hr) (normal range 0~9) 52 56 42 30
CRP (mg/dL) (normal range 0-0.36) 12.23 18.70 0.45 0.09

HOMA IR Index: HOMA Insulin Index

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