A Case of Epstein-Barr Virus-Related Dacryoadenitis

Sang Myung Kim; Jin Sook Yoon

doi:10.3341/jkos.2014.55.9.1372

Journal List > J Korean Ophthalmol Soc > v.55(9) > 1009787

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kim and Yoon: A Case of Epstein-Barr Virus-Related Dacryoadenitis

Case Report

J Korean Ophthalmol Soc 2014;55(9):1372-1375.

Published online: 2 September 2014

DOI: https://doi.org/10.3341/jkos.2014.55.9.1372

A Case of Epstein-Barr Virus-Related Dacryoadenitis

Sang Myung Kim, MD, Jin Sook Yoon, MD, PhD

Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Korea

Address reprint requests to Jin Sook Yoon, MD, PhD, Department of Ophthalmology, Severance Hospital, #50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea, Tel: 82-2-2228-3570, Fax: 82-2-312-0541, E-mail: yoonjs@yuhs.ac

Received 17 January 2014 Revised 12 March 2014 Accepted 17 July 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

To report a case of Epstein-Barr virus-related dacryoadenitis.

Case summary

A 19-year-old female presented with pain, swelling and redness of both upper eyelids. She experienced rhinorrhea, cough and fever for the previous two weeks. Physical exam showed bilateral cervical lymph node enlargement, and orbital computed tomography (CT) revealed diffuse enlargement and inflammation of both lacrimal glands. Serological testing revealed elevated titers for Epstein-Barr virus nuclear antigen immunoglobulin G (IgG) and Epstein-Barr viral capsid antigens IgG and immunoglobulin M (IgM). Based on these results, clinical diagnosis of Epstein-Barr virus-related acute dacryoadenitis was made. The inflammation subsided after conservative management. Relapse was not observed during the three-month follow-up period.

Conclusions

Based on acute bilateral lacrimal gland enlargement, systemic symptoms such as fever, rhinorrhea, cough, lymphadenopathy and serologically-positive results for Epstein-Barr virus, Epstein-Barr virus-related acute dacryoadenitis can be clinically diagnosed and treated with conservative therapy.

Keywords: Acute dacryoadenitis, Epstein-Barr virus, Painful eyelid swelling

References

1. Rhem MN, Wilhelmus KR, Jones DB. Epstein-Barr virus dacryoadenitis. Am J Ophthalmol. 2000; 129:372–5.

2. Wilhelmus KR. Mumps. Gold DH, Weingeist TA, editors. The eye in systemic disease. Philadelphia: JB Lippincott;1990. p. 262–4.

3. Fitzsimmons TD, Wilson SE, Kennedy RH. Infectious dacryoadenitis. Pepose JS, Holland GN, Wilhelmus KR, editors. Ocular infection and immunity. St. Louis: CV Mosby;1996. p. 1341–5.

4. Massaro BM, Tabbara KF. Infections of the lacrimal apparatus. Tabbara KF, Hyndiuk RA, editors. Infections of the eye. Boston: Little Brown & Co.;1996. p. 551–8.

5. Herken H. Beitrag zur pathologischen Histologie der Tränendrüse. Arch Augenheilkd. 1936; 110:61–75.

6. Niederman JC, McCollum RW, Henle G, Henle W. Infectious mononucleosis. Clinical manifestations in relation to EB virus antibodies. JAMA. 1968; 203:205–9.

7. Yuen SJ, Rubin PA. Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol. 2003; 121:491–9.

8. Rai P, Shah SA, Kirshan H. Acute Dacryadenitis-analysis of 23 cases. Med Channel. 2009; 15:71–6.

9. Belanger C, Zhang KS, Reddy AK, et al. Inflammatory disorders of the orbit in childhood: a case series. Am J Ophthalmol. 2010; 150:460–3.

Figure 1.

(A) Erythematous swelling of both the upper eyelids at the first visit. (B) No relapse of dacryoadenitis at 3 months after conservative therapy.

Figure 2.

(A) Orbital computed tomogram without enhancement shows both lacrimal glands enlargement. (B) Axial view shows preseptal soft tissue swelling.

TOOLS

Similar articles