Abstract
Purpose
To compare macular thickness measurements obtained from time domain optical coherence tomography (TD-OCT) and 2 spectral domain (SD) OCTs and to evaluate their repeatability and agreement in normal subjects and diabetic macular edema patients.
Methods
Fifty-four healthy, normal subjects and 26 diabetic macular edema patients were participated in this study. In a randomly selected eye from each subject, two serial macular measurements were obtained from TD-OCT (Stratus OCT) and SD-OCTs (Cirrus HD-OCT, Spectralis HRA+OCT) by an experienced technician in random order. Nine areas of macular thickness map and repeatabilities obtained by the 3 OCTs were compared.
Results
In relative repeatability, SD-OCT showed better results overall compared to TD-OCT. Macular thickness was greatest in the Spectralis HRA+OCT in both normal subjects and diabetic macular edema patients, followed by Cirrus HD-OCT and Stratus OCT. In normal subjects, regardless of the type of comparison between the machines there was a statistically significant difference in all 9 areas.
Conclusions
While the TD-OCT and the 2 SD-OCTs are reliable for macular thickness measurement, SD-OCT has better measurement repeatability compared with TD-OCT. Because macular measurements obtained from the 3 OCT systems cannot be interchanged, an effort should be made to standardize the measurement of each system.
References
1. Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008; 27:45–88.
2. van Velthoven ME, Faber DJ, Verbraak FD, et al. Recent developments in optical coherence tomography for imaging the retina. Prog Retin Eye Res. 2007; 26:57–77.
3. Gupta V, Gupta P, Singh R, et al. Spectral-Domain Cirrus High-Definition Optical Coherence Tomography Is Better than Time-Domain Stratus Optical Coherence Tomography for Evaluation of Macular Pathologic Features in Uveitis. Am J Ophthalmol. 2008; 145:1018–22.
4. Leung CK, Chan WM, Yung WH, et al. Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study. Ophthalmology. 2005; 112:391–400.
5. Kanadani FN, Hood DC, Grippo TM, et al. Structural and functional assessment of the macular region in patients with glaucoma. Br J Ophthalmol. 2006; 90:1393–7.
6. Chen TC, Cense B, Pierce MC, et al. Spectral Domain Optical Coherence Tomotraphy: Ultra-high Speed, Ultra-high Resolution Ophthalmic Imaging. Arch Ophthalmol. 2005; 123:1715–20.
7. Yi K, Chen TC, de Boer JF. Spectral domain optical coherence tomography. Techniques in Ophthalmology. 2006; 4:170–4.
8. Age-Related Eye Disease Study Group. The Age-Related Eye Disease Study Sevberity Scale for Age Related Macular Degeneration: Areds Report No. 17. Arch Ophthalmol. 2005; 123:1484–98.
9. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986; 1:307–10.
10. Bland JM, Altman DG. Comparing methods of measurement: why plotting difference against standard method is misleading. Lancet. 1995; 346:1085–7.
11. Leung CK, Cheung CY, Weinreb RN, et al. Comparison of Macular Thickness Measurements between Time Domain and Spectral Domain Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2008; 49:4893–7.
12. Kakinoki M, Sawada O, Sawada T, et al. Comparison of macular thickness between Cirrus HD-OCT and Stratus OCT. Ophthalmic Surg Lasers Imaging. 2009; 40:135–40.
13. Forooghian F, Cukras C, Meyerle CB, et al. Evaluation of Time Domain and Spectral Domain Optical Coherence Tomography in the Measurement of Diabetic Macular Edema. Invest Ophthalmol Vis Sci. 2008; 49:4290–6.
14. Massin P, Vicaut E, Haouchine B, et al. Reproducibility of retinal mapping using optical coherence tomography. Arch Ophthalmol. 2001; 119:1135–42.
15. Polito A, Del Borrello M, Isola M, et al. Repeatability and reproducibility of fast macular thickness mapping with stratus optical coherence tomography. Arch Ophthalmol. 2005; 123:1330–7.
16. Gurses-Ozden R, Teng C, Vessani R, et al. Macular and retinal nerve fiber layer thickness measurement reproducibility using optical coherence tomography (OCT-3). J Glaucoma. 2004; 13:238–44.