Journal List > Transl Clin Pharmacol > v.24(4) > 1082630

Holford: Absorption and Half-Life

Abstract

This tutorial deals with basic concepts of absorption processes and links previous tutorials on clearance and volume of distribution to introduce the concept of half-life. The time course of both absorption and elimination are commonly described using a half-life. Half-life can also be used to describe drug accumulation. Understanding the principles underlying the time course of absorption and elimination are essential in pharmacotherapy and clinical pharmacology.

Figure 1
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Figure 2
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Figure 3
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Figure 4
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Table 1.
Time % Css Concentration
0 0 100
1 50 50
2 75 25
3 87.5 12.5
4 93.8 6.25
5 96.9 3.1
6 98.4 1.6
7 99.2 0.8
8 99.6 0.4
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