Advantages and disadvantages of biomaterials for organoid culture.
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 |
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|---|---|---|---|---|
| Matrigel | Natural polymers | dECM | Synthetic polymers | |
| Advantages |
Built-in complex mixture of nutrients and proteins Readily available commercialized product Easy to handle |
Inertness Low toxicity Biodegradability |
Low toxicity Closely mimics native ECM High bioactivity Biodegradability |
Chemically defined Xenogeneic-free Tunable mechanical and degradation properties |
| Disadvantages |
Not clinically applicable Poorly defined Low mechanical strength Lot-to-lot variability Lacks tissue-specific ECM compositions |
Low mechanical strength Lacks tissue-specific ECM compositions |
Poorly defined Low mechanical strength Rapid degradation |
Low bioactivity Low cell adhesion Lacks tissue-specific ECM compositions Difficult and expensive synthesis procedure |