In this issue, 1 brief and 4 original articles have been published.
Kim HA, et al.
This study analyzed psychotropic drug prescriptions for elderly Korean osteoarthritis patients from 2011–2020. While overall prevalent prescription rates declined slightly, long-term use increased post-2018. Opioids and benzodiazepines were most common. Notably, prescriptions of drugs with limited OA evidence and elderly safety concerns rose, particularly anti-epileptics and certain antidepressants, both in patients with and without psychiatric comorbidities. This suggests potential off-label use and highlights the need for safer OA pain management strategies.
Yeon DK, et al.
This study examined the link between physical activity and type 2 diabetes in over 2 million Koreans. A non-linear relationship was found, with the lowest diabetes risk at 1,028 MET-min/week. Exceeding this increased risk. Combining moderate and vigorous activity, especially 300–600 MPA and over 600 VPA weekly, showed the lowest risk. Weekend and regular activity both reduced risk compared to inactivity, with no difference between them. PA frequency didn't significantly impact diabetes prevalence.
Kim YJ, et al.
This study examined COVID-19 in 11 immunocompromised children. They recovered quickly with low viral loads in saliva. Most developed limited antibody responses, but showed enhanced IFN-γ and IL-18 immune responses, without excessive inflammation. Rapid viral clearance was observed. This suggests a distinct immune response in these children, despite limited antibody production. Further studies comparing immune cell function in both immunocompromised and non-immunocompromised children are needed.
Kim K, et al.
This study examined 5-year mortality after hip fracture surgery in elderly patients. Frailty (high Hip-MFS) and postoperative complications significantly increased mortality risk. The 60.4% died within 5 years. Frailty had a stronger impact than complications. Even patients with low frailty but complications had better survival than frail patients without complications. This highlights the importance of frailty assessment for predicting long-term outcomes after hip fracture surgery.
Cho Y, et al.
QCG, an AI-ECG analysis, improved urgent coronary angiography decisions in acute chest pain cases. It increased accuracy for ACS, particularly occlusive CAD, compared to conventional methods, demonstrating AI's potential in emergency diagnostics.