Journal List > Korean J Occup Environ Med > v.22(4) > 1125631

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Jung, Kim, Kim, Jung, Choi, Kim, Park, and Jung: The Brain Pathology on Recovery of Brain MRI after Manganese Administration in Rats
Original Article

Korean Journal of Occupational and Environmental Medicine 2010; 22(4): 371-377.

Published online: 31 December 2010

DOI: https://doi.org/10.35371/kjoem.2010.22.4.371

The Brain Pathology on Recovery of Brain MRI after Manganese Administration in Rats

Ji Hyeon Jung, Jung Il Kim, Se Young Kim, Min Ho Jung1, Soon Sub Choi2, Soo Jin Kim3, Young Jin Park4, Kap Yeol Jung

Department of Occupational & Environmental Medicine, College of Medicine, Dong-A University, Korea.

1Department of Microbiology, College of Medicine, Dong-A University, Korea.

2Department of Radiology, College of Medicine, Dong-A University, Korea.

3Department of Pathology, College of Medicine, Dong-A University, Korea.

4Department of Family Medicine, College of Medicine, Dong-A University, Korea.

Corresponding author (kimji@dau.ac.kr)

Received 29 September 2010       Revised 6 December 2010       Accepted 17 December 2010

Copyright © 2010 The Korean Society of Occupational and Environmental Medicine

Abstract

Objectives

This study was carried out to investigate the effect on manganese on the brain of Sprague-Dawley rats, with particular focus on changes to anatomical pathology when brain MRI was recovered after manganese administration.

Methods

There were 15 rats divided into 3 groups of 5 based on dose of manganese: control group, low dose group (10 mg/kg), and high dose group (40 mg/kg). Each dosing group received an injection of normal saline and manganese via the tail vein once a week for 4 weeks. And then, the rats were observed for 12 weeks after stopping manganese administration. Next, each rat underwent a brain MRI and then each was sacrificed. After the rats were killed, the concentrations of blood manganese were measured, and pathologic examinations of the brain were performed.

Results

The signal intensity of basal ganglia on T1-weighted imaging of brain MRI did not differ between dosing groups. However, the ratio of neuron/glial cell in the basal ganglia was decreased in the low- and high-dose groups compared to the control group.

Conclusions

This study showed that the damage of neuron in basal ganglia might be permanent after signal intensity of basal ganglia on T1-weighted imaging of brain MRI was recovered.

Keywords: Manganese, Brain, MRI, Pathology

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