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Kang, Shin, Cui, and Kim: VP7 Genotypes of Group A Rotavirus Isolated from Infants and Toddlers with Rotavirus Gastroenteritis in Jeju
Original Article

Korean Journal of Pediatric Gastroenterology and Nutrition 2006; 9(2): 147-152.

Published online: 30 September 2006

DOI: https://doi.org/10.5223/kjpgn.2006.9.2.147

VP7 Genotypes of Group A Rotavirus Isolated from Infants and Toddlers with Rotavirus Gastroenteritis in Jeju

Ki Soo Kang, Kyung Sue Shin, Xiu Ji Cui*, Wonyong Kim†

Department of Pediatrics, Cheju National University College of Medicine, Jeju, Korea.

*Department of Internal Medicine, Cheju National University College of Medicine, Jeju, Korea.

†Department of Microbiology, Chung-Ang University College of Medicine, Seoul, Korea.

kskang@cheju.ac.kr

Copyright © 2006 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition

Abstract

PURPOSE

Efficacy of the new rotavirus vaccines (Rotarix®, RotaTeq®) recently developed can be affected by the rotavirus genotypes prevalent in communities. We performed this study to identify the recent distribution of rotavirus genotypes prevalent in Jeju.

METHODS

Genotyping of human rotaviruses was performed using 81 samples collected from 154 inpatients and outpatients with rotavirus gastroenteritis at Cheju National University Hospital between July 2005 and June 2006. All six (1, 2, 3, 4, 8, 9) G serotypes were identified by amplification of segments of the gene for VP7 using the reverse transcription-polymerase reaction (RT- PCR).

RESULTS

The results of RT-PCR for 81 samples were all positive. G typing of the VP7 protein showed that G1 was the most dominant circulating genotype (65.5%) followed by G2 (14.8%), G3 (13.6%), G8 (1.2%), G9 (1.2%), G4 (0%), and a combination of G1/G3 (3.7%).

CONCLUSION

This distribution of rotavirus VP7 genotypes in Jeju is different from that in other domestic areas; the most dominant circulating genotype was G1.

Keywords: Genotype, Rotavirus, Jeju

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