Journal List > Korean J Pediatr Gastroenterol Nutr > v.10(1) > 1110205

Korean J Pediatr Gastroenterol Nutr. 2007 Mar;10(1):71-75. Korean.
Published online Mar 31, 2007.
Copyright © 2007 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
A Case of Gastrointestinal Stromal Tumor in a Child
Kyung Bin Yun, Jae Young Kim, Jae Hong Ryu, Ji Young Sul,* and Dae Young Kang
Department of Pediatrics, College of Medicine,Chungnam National University, Daejeon, Korea.
*Department of Surgery, College of Medicine,Chungnam National University, Daejeon, Korea.
Department of Pathology, College of Medicine,Chungnam National University, Daejeon, Korea.

Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal tumors of the digestive tract. They have been commonly observed in adults but have been rarely described in children. They arise typically from the intestinal wall and rarely in the mesentery, omentum, or retroperitoneum. GISTs originate from the interstitial cell of Cajal and are characterized by overexpression of the receptor tyrosine kinase c-kit. Up to 94% of these tumors express the CD117 on immunohistochemical stain. Surgery is the main modality of treatment for primary resectable GIST. Completely resectable GIST with low risk has excellent prognosis after primary surgical intervention, with over 90% of the 5-year survival. We report a case of 10-year-old girl presenting with an upper gastrointestinal bleeding caused by gastrointestinal stromal tumor.

Keywords: Gastrointestinal stromal tumors (GISTs); Interstitial cell of Cajal; Receptor tyrosine kinase c-kit; CD117; Immunohistochemical stain