Journal List > Korean J Pediatr Gastroenterol Nutr > v.10(2) > 1110189

Korean J Pediatr Gastroenterol Nutr. 2007 Sep;10(2):179-184. Korean.
Published online Sep 30, 2007.  https://doi.org/10.5223/kjpgn.2007.10.2.179
Copyright © 2007 The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition
Risk Factors of Non-alcoholic Steatohepatitis in Childhood Obesity
Eun Sil Yun, Yong Hun Park and Kwang Hae Choi
Department of Pediatrics, Yeungnam University College of Medicine, Daegu, Korea.
Abstract

PURPOSE

Obesity has recently emerged as a significant health problem in the pediatric population, and the prevalence of non-alcoholic fatty liver disease is increasing in tandem with a significant rise in childhood obesity. Therefore, this study was conducted to clarify the risk factors of non-alcoholic steatohepatitis in obese children.

METHODS

We enrolled 84 obese children who visited the pediatric obesity clinic at Yeung-Nam university hospital. The patients were divided into two groups based on their alanine aminotransferase (ALT) level (separated at 40 IU/L), and the mean of ages, total cholesterol levels, HDL-cholesterol levels, LDL-cholesterol levels, triglyceride (TG) levels, as well as the mean obesity index, and body fat percentage of the two groups were then compared.

RESULTS

When the mean of ages (10.5±1.6 vs. 10.7±2.0 years), total cholesterol levels (183.0±29.1 vs. 183.7±31.3 mg/dL), HDL-cholesterol levels (53.0±10.2 vs. 55.7±13.0 mg/dL), LDL-cholesterol levels (113.4±30.2 vs. 113.0±30.0 mg/dL), triglyceride levels (99.4±62.9 vs. 114.2±47.3 mg/dL), obesity indexes (44.7±12.2 vs. 47.9±15.1%), and body fat percentages (32.7±5.0 vs. 34.0±4.8%) of group 1 (ALT≤40 IU/L) were compared with those of group 2 (ALT≥41 IU/L), no significant differences were observed (p>0.05). However, hypertriglyceridemia (TG≥110 mg/dL) was more frequent in group 2 than in group 1 (p=0.023).

CONCLUSION

TG may be an important risk factor in non-alcoholic steatohepatitis and further study regarding the risk factors in non-alcoholic steatohepatitis is required

Keywords: Obesity; Non-alcoholic steatohepatitis; Risk factor; Triglyceride