Journal List > Korean J Health Promot > v.18(3) > 1102147

Korean J Health Promot. 2018 Sep;18(3):113-118. Korean.
Published online September 30, 2018.
Copyright © 2018 Korean Society for Health Promotion and Disease Prevention
Relationship between Metabolic Syndrome and Uric Acid to Creatinine Ratio in Korean Adults: Korea National Health and Nutrition Examination Survey 2016
Sae-Ron Shin and A Lum Han
Department of Family Medicine, Wonkwang University Hospital, Iksan, Korea.

Corresponding author : A Lum Han, MD, PhD. Department of Family Medicine, Wonkwang University Hospital, 501 Iksan-daero, Iksan 54536, Korea. Tel: +82-63-859-1300, Fax: +82-63-859-1306, Email:
Received August 02, 2018; Accepted September 25, 2018.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



While the correlation between metabolic syndrome (MS) and serum uric acid (sUA) levels has already been identified, the correlation between MS and the sUA/creatinine ratio has not been studied in Korea. Accordingly, the present study examined the correlation between MS and the sUA/creatinine ratio using data from the seventh Korea National Health and Nutrition Examination Survey (2016).


The study population consisted of healthy adults aged 19 years or older medical diseases. The five components of MS and the presence of MS were used as independent variables, while the sUA/creatinine ratio was selected as the dependent variable. After adjusting for confounding variables, a complex samples logistic regression test was performed to analyze the correlations between the sUA/creatinine ratio and MS and its components.


The following variables showed positive correlation with the sUA/creatinine ratio: systolic blood pressure (BP) (95% confidence interval [CI], 1.051–1.243; P=0.002), diastolic BP 1.144 (95% CI, 1.054–1.241; P=0.001), fasting blood sugar level 1.166 (95% CI, 1.070–1.271; P<0.001), triglyceride level 1.340 (95% CI, 1.259–1.427; P<0.001), high density lipoprotein level 1.163 (95% CI, 1.100–1.230; P<0.001), waist circumference 1.342 (95% CI, 1.239–1.455; P<0.001), and the presence of MS 1.041 (95% CI, 1.034–1.049; P≤0.001).


The findings of the present study demonstrated a statistically significant correlation between the sUA/creatinine ratio and the presence of MS as well as with each component of MS. The significance of the present study is that it is the first study to investigate Koreans.

Keywords: Metabolic syndrome; Uric acid; Creatinine


Table 1
Comparison of non-metabolic syndrome group and metabolic syndrome group in study participants
Click for larger image

Table 2
Crude odds ratios for MetS and components by serum uric acid to creatinine ratio
Click for larger image

Table 3
Adjusted odds ratios for MetS and components by serum uric acid to creatinine ratio
Click for larger image


This study was supported by Wonkwang University 2017 grant.

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