Journal List > Korean J Health Promot > v.18(3) > 1102147

Korean J Health Promot. 2018 Sep;18(3):113-118. Korean.
Published online September 30, 2018.  https://doi.org/10.15384/kjhp.2018.18.3.113
Copyright © 2018 Korean Society for Health Promotion and Disease Prevention
Relationship between Metabolic Syndrome and Uric Acid to Creatinine Ratio in Korean Adults: Korea National Health and Nutrition Examination Survey 2016
Sae-Ron Shin and A Lum Han
Department of Family Medicine, Wonkwang University Hospital, Iksan, Korea.

Corresponding author : A Lum Han, MD, PhD. Department of Family Medicine, Wonkwang University Hospital, 501 Iksan-daero, Iksan 54536, Korea. Tel: +82-63-859-1300, Fax: +82-63-859-1306, Email: qibosarang@naver.com
Received August 02, 2018; Accepted September 25, 2018.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


Abstract

Background

While the correlation between metabolic syndrome (MS) and serum uric acid (sUA) levels has already been identified, the correlation between MS and the sUA/creatinine ratio has not been studied in Korea. Accordingly, the present study examined the correlation between MS and the sUA/creatinine ratio using data from the seventh Korea National Health and Nutrition Examination Survey (2016).

Methods

The study population consisted of healthy adults aged 19 years or older medical diseases. The five components of MS and the presence of MS were used as independent variables, while the sUA/creatinine ratio was selected as the dependent variable. After adjusting for confounding variables, a complex samples logistic regression test was performed to analyze the correlations between the sUA/creatinine ratio and MS and its components.

Results

The following variables showed positive correlation with the sUA/creatinine ratio: systolic blood pressure (BP) (95% confidence interval [CI], 1.051–1.243; P=0.002), diastolic BP 1.144 (95% CI, 1.054–1.241; P=0.001), fasting blood sugar level 1.166 (95% CI, 1.070–1.271; P<0.001), triglyceride level 1.340 (95% CI, 1.259–1.427; P<0.001), high density lipoprotein level 1.163 (95% CI, 1.100–1.230; P<0.001), waist circumference 1.342 (95% CI, 1.239–1.455; P<0.001), and the presence of MS 1.041 (95% CI, 1.034–1.049; P≤0.001).

Conclusions

The findings of the present study demonstrated a statistically significant correlation between the sUA/creatinine ratio and the presence of MS as well as with each component of MS. The significance of the present study is that it is the first study to investigate Koreans.

Keywords: Metabolic syndrome; Uric acid; Creatinine

Tables


Table 1
Comparison of non-metabolic syndrome group and metabolic syndrome group in study participants
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Table 2
Crude odds ratios for MetS and components by serum uric acid to creatinine ratio
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Table 3
Adjusted odds ratios for MetS and components by serum uric acid to creatinine ratio
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Notes

This study was supported by Wonkwang University 2017 grant.

References
1. Park E, Kim J. Gender- and age-specific prevalence of metabolic syndrome among Korean adults: analysis of the fifth Korean National Health and Nutrition Examination Survey. J Cardiovasc Nurs 2015;30(3):256–266.
2. Quiñones Galvan A, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D, et al. Effect of insulin on uric acid excretion in humans. Am J Physiol 1995;268(1 Pt 1):E1–E5.
3. Nakagawa T, Hu H, Zharikov S, Tuttle KR, Short RA, Glushakova O, et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am J Physiol Renal Physiol 2006;290(3):F625–F631.
4. Gagliardi AC, Miname MH, Santos RD. Uric acid: a marker of increased cardiovascular risk. Atherosclerosis 2009;202(1):11–17.
5. Fu CC, Wu DA, Wang JH, Yang WC, Tseng CH. Association of C-reactive protein and hyperuricemia with diabetic nephropathy in Chinese type 2 diabetic patients. Acta Diabetol 2009;46(2):127–134.
6. Guo L, Cheng Y, Wang X, Pan Q, Li H, Zhang L, et al. Association between microalbuminuria and cardiovascular disease in type 2 diabetes mellitus of the Beijing Han nationality. Acta Diabetol 2012;49 Suppl 1:S65–S71.
7. Ruggiero C, Cherubini A, Ble A, Bos AJ, Maggio M, Dixit VD, et al. Uric acid and inflammatory markers. Eur Heart J 2006;27(10):1174–1181.
8. Chen N, Wang W, Huang Y, Shen P, Pei D, Yu H, et al. Community-based study on CKD subjects and the associated risk factors. Nephrol Dial Transplant 2009;24(7):2117–2123.
9. Coresh J, Wei GL, McQuillan G, Brancati FL, Levey AS, Jones C, et al. Prevalence of high blood pressure and elevated serum creatinine level in the United States: findings from the third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 2001;161(9):1207–1216.
10. Muntner P, He J, Hamm L, Loria C, Whelton PK. Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol 2002;13(3):745–753.
11. Gu L, Huang L, Wu H, Lou Q, Bian R. Serum uric acid to creatinine ratio: a predictor of incident chronic kidney disease in type 2 diabetes mellitus patients with preserved kidney function. Diab Vasc Dis Res 2017;14(3):221–225.
12. Durmus Kocak N, Sasak G, Aka Akturk U, Akgun M, Boga S, Sengul A, et al. Serum uric acid levels and uric acid/creatinine ratios in stable chronic obstructive pulmonary disease (COPD) patients: are these parameters efficient predictors of patients at risk for exacerbation and/or severity of disease. Med Sci Monit 2016;22:4169–4176.
13. Al-Daghri NM, Al-Attas OS, Wani K, Sabico S, Alokail MS. Serum uric acid to creatinine ratio and risk of metabolic syndrome in Saudi type 2 diabetic patients. Sci Rep 2017;7(1):12104.
14. Li M, Gu L, Yang J, Lou Q. Serum uric acid to creatinine ratio correlates with β-cell function in type 2 diabetes. Diabetes Metab Res Rev 2018;34(5):e3001.
15. Santos RD. Elevated uric acid, the metabolic syndrome and cardiovascular disease: cause, consequence, or just a not so innocent bystander? Endocrine 2012;41(3):350–352.
16. Johnson RJ, Titte S, Cade JR, Rideout BA, Oliver WJ. Uric acid, evolution and primitive cultures. Semin Nephrol 2005;25(1):3–8.
17. Reaven G. Why a cluster is truly a cluster: insulin resistance and cardiovascular disease. Clin Chem 2008;54(5):785–787.
18. Wang HJ, Shi LZ, Liu CF, Liu SM, Shi ST. Association between uric acid and metabolic syndrome in elderly women. Open Med (Wars) 2018;13:172–177.
19. Chang IH, Han JH, Myung SC, Kwak KW, Kim TH, Park SW, et al. Association between metabolic syndrome and chronic kidney disease in the Korean population. Nephrology (Carlton) 2009;14(3):321–326.
20. Alizadeh S, Ahmadi M, Ghorbani Nejad B, Djazayeri A, Shab-Bidar S. Metabolic syndrome and its components are associated with increased chronic kidney disease risk: evidence from a meta-analysis on 11 109 003 participants from 66 studies. Int J Clin Pract. 2018 May 23;
[Epub ahead of print].
21. Thomas G, Sehgal AR, Kashyap SR, Srinivas TR, Kirwan JP, Navaneethan SD. Metabolic syndrome and kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol 2011;6(10):2364–2373.
22. Tanner RM, Brown TM, Muntner P. Epidemiology of obesity, the metabolic syndrome, and chronic kidney disease. Curr Hypertens Rep 2012;14(2):152–159.
23. Wahba IM, Mak RH. Obesity and obesity-initiated metabolic syndrome: mechanistic links to chronic kidney disease. Clin J Am Soc Nephrol 2007;2(3):550–562.