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Erdem, Güleç, Aktaş, Yildirim, and Kiziltunç: Increased Serum Level of P-Selectin in Patients with Lichen Planus
Original Article
Yonsei Medical Journal

Yonsei Medical Journal 2004; 45(2): 215-218.

Published online: 17 February 2009

DOI: https://doi.org/10.3349/ymj.2004.45.2.215

Increased Serum Level of P-Selectin in Patients with Lichen Planus

Teoman Erdem1, A. İhsan Güleç1, Akın Aktaş1, Abdulkadir Yildirim2, Ahmet Kiziltunç2

1Department of Dermatology, Atatürk University Medicine, Erzurum, Turkey.

2Department of Biochemistry, Atatürk University Medicine, Erzurum, Turkey.

Reprint address: requests to Dr. Teoman Erdem, Department of Dermatology, Ataturk University Medicine, 25240 Erzurum, Turkey. Tel: 90 442 2361212/1699, Fax: 90 442 2361301, mterdem@hotmail.com

Received 26 April 2003       Accepted 26 September 2003

Copyright © 2004 The Yonsei University College of Medicine

Abstract

Lichen planus (LP) is a common, pruritic and inflammatory disease of the skin, hair follicles and mucous membranes. Immunologic mechanisms, especially cell-mediated immunity, play a major role in triggering the clinical expression of the disease. P-selectin is an adhesion molecule present within endothelial cells and mediates endothelial-leukocyte interactions. Therefore, it is considered that P-selectin plays an important role in LP. The aim of our study is to research the relation between P-selectin and LP.
Serum P-selectin levels were determined with the enzyme-linked immunosorbent sandwich assay method in sera from 40 LP patients and 40 healthy controls.
The serum levels of P-selectin were statistically significantly higher in the patients than in healthy controls (p < 0.05), in female patients (39.32 ± 11.34 pg/ml) than in male patients (31.93 ± 9.83 pg/ml) (p < 0.01), and in the patients with eruptive form (40.27 ± 9.32 pg/ml) than in those with the localised (32.83 ± 9.93 pg/ml) and hypertrophic (31.72 ± 8.39 pg/ml) forms (both p < 0.01).
In conclusion, we found a meaningful relation between LP and serum P-selectin levels.

Keywords: Lichen planus, P-selectin

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