Liver transplantation is the only hope for patients with terminal liver cirrhosis. Liver transplantation has evolved rapidly over the past two dacades, and its indication has been expanded. The most common indication of liver transplantation is terminal liver cirrhosis from any cause (hepatitis B, hepatitis C/non-A,non-B, alcoholic, autoimmune and others). Other indications are hepatic neoplasm, fulminant hepatic failure, biliary atresia, primary biliary cirrhosis, primary sclerosing cholangitis, and some metabolic diseases. Liver transplantation can be always considered as an option for life-saving treatment in case of failure of liver function. So we should consider absolute contraindications of liver transplantation : active substance abuse, unstableactive cardiopulmonary disease, incurable extrahepatic malignancy, active uncontrolled and untreatable sepsis, active HIV infection (unresponsive to treatment), inadequate social support, extreme psychosocial dysfunction, and extensive vascular thrombosis precluding liver transplantation. For improved survival and better prognosis in cases of liver transplantation much attention is needed for careful long-term follow-up and surveillance for cardiovascular risk factors, de novo malignancy, and metabolic factors.