Journal List > J Korean Breast Cancer Soc > v.7(3) > 1076724

J Korean Breast Cancer Soc. 2004 Sep;7(3):148-153. Korean.
Published online September 30, 2004.  https://doi.org/10.4048/jkbcs.2004.7.3.148
Copyright © 2004 Korean Breast Cancer Society
Expression of E-cadherin and Clinical Correlation in Patients with Breast Carcinoma
Jung Man Kim, Tae Yoon Kim, Dan Song, Sung Yong Kim, Moo Jun Baek, Moon Soo Lee, Chang Ho Kim, Seung Ha Yang,1 Min Hyuk Lee and Moo Sik Cho
Department of Surgery, College of Medicine, Soonchunhyang University, Cheonan, Korea.
1Department of Pathology, College of Medicine, Soonchunhyang University, Cheonan, Korea.
Received April 07, 2004; Accepted August 13, 2004.

Abstract

Purpose

E-cadherin is a Ca (2+)-dependent cell adhesion molecule that plays an important role in normal growth and development via the mediation of homotypic, homophilic cell-cell interactions. Recent studies suggest that E-cadherin may also be important in neoplastic progression, particularly as a suppressor of invasion.

Methods

To evaluate the expression of E-cadherin, according to the histopathological features and the relation between E-cadherin and prognosis in breast carcinoma, immunohistochemical staining, using mouse HECD-1 was performed for 66 cases of breast carcinoma.

Results

The breast carcinomas showed loss or marked reduction of E-cadherin expression in 42 (63.6%) of the 66 cases. In a multivariate analysis, E-cadherin expression had no independent prognostic value, while the axillary lymph node status, tumor diameter, and TNM stage were independent prognostic factors. The results indicate that E-cadherin expression was related to several histological features in breast cancer, but had no independent prognostic value over standard prognostic factors. No significant correlation was found between E-cadherin expression and tumor size, stage, nuclear grade, lymph node status, histologic type, or hormonal status.

Conclusion

The loss or marked reduction of E-cadherin expression in breast carcinomas was not related to the prog nosis of the patients.

Keywords: Breast cancer; E-cadherin