A Case of Paget's Disease Involving Pelvic Bone in a Patient with Tophaceous Gouty Arthritis

Eun-Jung Park; Sun Hyung Kim; Jinseok Kim

doi:10.4078/jrd.2017.24.1.60

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Park, Kim, and Kim: A Case of Paget's Disease Involving Pelvic Bone in a Patient with Tophaceous Gouty Arthritis

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J Rheum Dis 2017;24(1):60-61.

Published online: 31 October 2017

DOI: https://doi.org/10.4078/jrd.2017.24.1.60

A Case of Paget's Disease Involving Pelvic Bone in a Patient with Tophaceous Gouty Arthritis

Eun-Jung Park¹, Sun Hyung Kim², Jinseok Kim¹

¹Department of Medicine, Jeju National University School of Medicine, Jeju, Korea

²Department of Laboratory Medicine, Jeju National University School of Medicine, Jeju, Korea

Corresponding to: Jinseok Kim, Division of Rheumatology, Department of Internal Medicine, Jeju National University School of Medicine, 102 Jejudaehak-ro, Jeju 63243, Korea. E-mail: slera@yahoo.com

Received 12 October 2016 Revised 28 December 2016 Accepted 28 December 2016

This is a Open Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

REFERENCES

1. Bolland MJ, Cundy T. Paget's disease of bone: clinical review and update. J Clin Pathol. 2013; 66:924–7.

2. Ralston SH, Langston AL, Reid IR. Pathogenesis and management of Paget's disease of bone. Lancet. 2008; 372:155–63.

3. Lluberas-Acosta G, Hansell JR, Schumacher HR Jr. Paget's disease of bone in patients with gout. Arch Intern Med. 1986; 146:2389–92.

4. Altman RD. Musculoskeletal manifestations of Paget's disease of bone. Arthritis Rheum. 1980; 23:1121–7.

Figure 1.

(A) Multiple distal interphalangeal joints destruction with tophi on plain radiography of hands, (B) active arthritis and osteomyelitis bilateral hands on delayed phase of 3-phase bone scan and (C) active bone lesion on pelvic bone, left femoral head and proximal femur on bone scan.

Figure 2.

Sunburst lesion of left proximal femur on plain radiography of hips (arrow).

Figure 3.

Bone marrow biopsy. (A) Irregularly thickened bony trabeculae with distinct cement lines (H&E stain, ×100), and (B) increased activity of multinucleated osteoclast (arrowhead) and osteoblast (arrow) (H&E stain, ×200).

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