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Oh, Jun, and Ko: Childhood Chilblain Lupus Erythematosus
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J Rheum Dis 2015;22(4):269-270.

Published online: 31 October 2015

DOI: https://doi.org/10.4078/jrd.2015.22.4.269

Childhood Chilblain Lupus Erythematosus

Eui Hyun Oh1, Jae-Bum Jun2, Joo Yeon Ko1

1Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea

2Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea

Corresponding to: Joo Yeon Ko, Department of Dermatology, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea. E-mail: drko0303@hanyang.ac.kr

Received 7 April 2015       Revised 28 April 2015       Accepted 13 May 2015

Copyright © 2015 The Korean College of Rheumatology

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

REFERENCES

1. Hedrich CM, Fiebig B, Hauck FH, Sallmann S, Hahn G, Pfeiffer C, et al. Chilblain lupus erythematosus: a review of literature. Clin Rheumatol. 2008; 27:949–54.
2. Viguier M, Pinquier L, Cavelier-Balloy B, de la Salmonière P, Cordoliani F, Flageul B, et al. Clinical and histopathologic features and immunologic variables in patients with severe chilblains. A study of the relationship to lupus erythematosus. Medicine (Baltimore). 2001; 80:180–8.
3. Tüngler V, Silver RM, Walkenhorst H, Günther C, Lee-Kirsch MA. Inherited or de novo mutation affecting aspartate 18 of TREX1 results in either familial chilblain lupus or Aicardi-Goutières syndrome. Br J Dermatol. 2012; 167:212–4.
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4. Abe J, Izawa K, Nishikomori R, Awaya T, Kawai T, Yasumi T, et al. Heterozygous TREX1 p. Asp18Asn mutation can cause variable neurological symptoms in a family with Aicardi-Goutieres syndrome/familial chilblain lupus. Rheumatology (Oxford). 2013; 52:406–8.
5. Günther C, Hillebrand M, Brunk J, Lee-Kirsch MA. Systemic involvement in TREX1-associated familial chilblain lupus. J Am Acad Dermatol. 2013; 69:e179–81.
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Figure 1.
(A) Multiple erythematosus scaly plaques were observed on dorsal aspects of patient's hands. (B) Similarily, his father showed erytheamtous skin lesions on dorsum of hands.
jrd-22-269f1.tif
Figure 2.
Erythematous to pur-puric swollen scaly patches were noted on the ear of the patient (A, B) and his father (C, D).
jrd-22-269f2.tif
Figure 3.
(A) Histopathologic examination revealed interface dermatitis and prominent periap-pendigeal, perivascular and peri-neural lymphohistiocytic infiltrates throughout the entire dermis (H&E, ×40). (B) Lesional direct immunofluorescence results showed granular deposits of immunoglobulin M in the basement membrane zone (×200).
jrd-22-269f3.tif
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