Journal List > J Rheum Dis > v.20(1) > 1064092

Park, Lee, Kim, Kim, Baek, and Park: A Case of Castleman's Disease Accompanied with Systemic Lupus Erythematosus

Abstract

Castleman's disease is a rare atypical lymphoproliferative disorder. Although HHV-8 has been reported to be a cause of Castleman's disease, the etiology and pathogenesis of the disease remains mostly unknown. We experienced a 51- year-old female patient who was concurrently diagnosed with Castleman's disease and systemic lupus erythematosus. Castleman's disease has been rarely reported in patients with systemic lupus erythematosus. Thus, we report the case and briefly discuss relevant articles.

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Figure 1.
Contrast enhanced CT and PET-CT show generalized lymph node enlargement (black arrow). (A) chest CT. (B) abdo-men and pelvis CT. (C) PET-CT.
jrd-20-59f1.tif
Figure 2.
Enlarged cervical Lymph node shows histologically hyaline vascular type Castleman's disease. (A) A lymphoid follicle including an atrophic germinal center surrounded by a thick mantle zone consists of small lymphocytes (black arrow) (H&E stain, ×200), (B) Hyalization in the small vessels (white arrow) (H&E stain, ×100)
jrd-20-59f2.tif
Figure 3.
Immunohistochemical staining is positive for CD3, CD20, CD21, bcl2. (A) CD3 (×100), (B) CD20 (×100), (C) CD21 (×100), (D) bcl2 (×100).
jrd-20-59f3.tif
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