1. Yin LL, Lin LL, Zhang L, Li L. Epimedium flavonoids ameliorate experimental autoimmune encephalomyelitis in rats by modulating neuroinflammatory and neurotrophic responses. Neuropharmacology. 2012. 63:851–862.

2. Lee YR, Hwang JK, Koh HW, Jang KY, Lee JH, Park JW, et al. Sulfuretin, a major flavonoid isolated from Rhus verniciflua, ameliorates experimental arthritis in mice. Life Sci. 2012. 90:799–807.

3. Herrick AL, Matucci Cerinic M. The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis. Clin Exp Rheumatol. 2001. 19:4–8.

4. Yamamoto T, Katayama I, Nishioka K. Nitric oxide production and inducible nitric oxide synthase expression in systemic sclerosis. J Rheumatol. 1998. 25:314–317.

5. Dooley A, Shi-Wen X, Aden N, Tranah T, Desai N, Denton CP, et al. Modulation of collagen type I, fibronectin and dermal fibroblast function and activity, in systemic sclerosis by the antioxidant epigallocatechin-3-gallate. Rheumatology (Oxford). 2010. 49:2024–2036.

6. Jun JB, Kim JK, Na YI, Han H, Paik SS, Kim SH, et al. Dietary flavonoid apigenin is not effective in preventing development of a bleomycin-induced murine model of scleroderma. J Rheum Dis. 2012. 19:206–211.

7. Ricupero DA, Poliks CF, Rishikof DC, Kuang PP, Goldstein RH. Apigenin decreases expression of the myofibroblast phenotype. FEBS Lett. 2001. 506:15–21.

8. Jun JB, Na YI, Kim TH, Yoo DH. Dietary flavonoid apigenin inhibits endothelin-1-induced contraction of collagen gel. Rheumatol Int. 2010. 30:1695–1697.

9. Vissiennon C, Nieber K, Kelber O, Butterweck V. Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin-are they prodrugs? J Nutr Biochem. 2012. 23:733–740.

10. Gradolatto A, Basly JP, Berges R, Teyssier C, Chagnon MC, Siess MH, et al. Pharmacokinetics and metabolism of apigenin in female and male rats after a single oral administration. Drug Metab Dispos. 2005. 33:49–54.