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Choi and Park: A Case of Cortical Vein Thrombosis in Wegener's Granulomatosis
Case Report
Journal of Rheumatic Diseases

Journal of Rheumatic Diseases 2012; 19(2): 108-111.

Published online: 30 April 2012

DOI: https://doi.org/10.4078/jrd.2012.19.2.108

A Case of Cortical Vein Thrombosis in Wegener's Granulomatosis

Jung Ran Choi, Won Park

Division of Rheumatology, Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.

Corresponding to: Won Park, Division of Rheumatology, Department of Internal Medicine, Inha University College of Medicine, Sinheung-dong 3-ga, Jung-gu, Incheon 400-711, Korea. parkwon@inha.ac.kr

Received 3 March 2011       Revised 22 September 2011       Accepted 22 September 2011

Copyright © 2012 by The Korean College of Rheumatology

(free-access):

This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Wegener's granulomatosis is an uncommon disease characterized by variable degrees of disseminated vasculitits involving both small arteries and veins. This disease is rarely associated with thrombosis. Isolated reports of intracranial thromboses of large and small vessels have been described in both adults and children. This report describes the first case of cortical vein thrombosis which was central nervous system manifestation in Wegener's granulomatosis.

Keywords: Cortical vein thrombosis, Wegener's granulomatosis

Figures and Tables

Figure 1
(A) 14 days prior to the incident, the venous sinus occlusion CT imaging is normal. (B) Accident when the underlying, the venous sinus thrombosis.
jrd-19-108-g001
Figure 2
(A) Right internal carotid artery angiography shows obstruction of right transverse sinus (arrow) and sigmoid sinus (small arrow) in venous phase, comparing normal left transverse sinus. (B) Right internal carotid arteriography shows total non-visualization in vein of Galen (arrow) and straight sinus (small arrow) and shows abnormal collateral vessels (white arrow) around the sinuses.
jrd-19-108-g002

References

1. Bacon PA. The spectrum of Wegener's granulomatosis and disease relapse. N Engl J Med. 2005. 352:330–332.
2. Nishino H, Rubino FA, DeRemee RA, Swanson JW, Parisi JE. Neurological involvement in Wegener's granulomatosis: an analysis of 324 consecutive patients at the Mayo Clinic. Ann Neurol. 1993. 33:4–9.
3. Mickle JP, McLennan JE, Lidden CW. Cortical vein thrombosis in Wegener's granulomatosis. Case report. J Neurosurg. 1977. 46:248–251.
4. von Scheven E, Lu TT, Emery HM, Elder ME, Wara DW. Thrombosis and pediatric Wegener's granulomatosis: acquired and genetic risk factors for hypercoagulability. Arthritis Rheum. 2003. 49:862–865.
5. Seror R, Mahr A, Ramanoelina J, Pagnoux C, Cohen P, Guillevin L. Central nervous system involvement in Wegener's granulomatosis. Medicine (Baltimore). 2006. 85:54–65.
6. de Groot K, Schmidt DK, Arlt AC, Gross WL, Reinhold-Keller E. Standardized neurologic evaluations of 128 patients with Wegener's granulomatosis. Arch Neurol. 2001. 58:1215–1221.
7. Seo P, Min YI, Holbrook JT, Hoffman GS, Merkel PA, Spiera R, et al. WGET Research Group. Damage caused by Wegener's granulomatosis and its treatment: prospective data from the Wegener's Granulomatosis Etanercept Trial (WGET). Arthritis Rheum. 2005. 52:2168–2178.
8. Ha YJ, Lee KH, Jung SY, Park HS, Lee SK, Park YB. A case of Wegener's granulomatosis presenting with cerebral infarction and intracerebral hemorrhage. J Korean Rheum Assoc. 2010. 17:283–288.
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