Journal List > J Rheum Dis > v.18(3) > 1063909

Seo, Son, Jung, Kim, Kim, Bae, and Kim: Survey of Current Trends for Diagnosis and Treatment in Korean Gout Patients

Abstract

Objective

The prevalence of gout has increased so accurate diagnosis and constant treatment is important in its management. The purpose this study was to examine the current trends in the diagnosis and treatment of gout patients in Korea.

Methods

We enrolled patients who were diagnosed as having gout and received treatment in university hospital between 2005 and 2008. From the survey, we assessed and analyzed the patient's baseline characteristics, clinical aspects of gout attack, medical institution and specialized department in the first gouty attack, medical institution and specialized department where the gout was initially diagnosed, methods of diagnosis, treatment during gout attack, and knowledge about gout in patients.

Results

A total of 136 patients were included in this study, out of which 123 (90.4%) were male and the mean age was 55.2 (range 25∼85) years. When patients experienced the first gout attack, the most common medical institution that they attended was a private clinic and the most common specialized department was orthopedics. Medication by oral route was the major method (80.9%) used for the treatment of gout, and the most common medication was a nonsteroidal antiinflammatory drug (NSAID) in 55.9%, allopurinol in 38.2% and colchicine in 20.6% of patients. Many gout patients inappropriately received allopurinol following signs of gout arthritis attack, with little information specifically about gout.

Conclusion

In our survey, many gout patients received inadequate medications for the treatment of gout and had little knowledge about the disease. For the adequate treatment of gout, patients and doctors need to be educated sufficiently.

References

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Table 1.
Baseline characteristics of patients in this study
  Total (n=136) Male (n=123, 90.4%) Female (n=13, 9.6%)
Age (year, mean± SD) 55.2±13.5 54.2±13.4 64.3±12.6
Comorbidity (n, %)      
  Hypertension 49 (36.0) 44 (35.8) 5 (38.5)
  Diabetes mellitus 15 (11.0) 14 (11.4) 1 (7.7)
  Angina 11 (8.1) 8 (6.5) 3 (23.1)
  Myocardial infarction 6 (4.4) 6 (4.9) 0 (0)
  Heart failure 9 (6.6) 8 (6.5) 1 (7.7)
  Hyperlipidemia 6 (4.4) 7 (5.7) 1 (7.7)
  Others 20 (14.7) 18 (14.6) 2 (15.4)
Diagnosed as gout previously (n, %) 115 (84.6) 106 (86.2) 9 (69.2)
Family history (n, %) 15 (11.0) 13 (10.6) 2 (15.4)
Body mass index (n, %)      
 <18.5 kg/m2 6 (4.4) 6 (4.9) 0 (0)
 18.5∼24.9 kg/m2 63 (46.3) 55 (44.7) 8 (61.5)
 >25 kg/m2 67 (49.3) 62 (50.4) 5 (38.5)
Table 2.
Medical institute and specialized department for treatment of first gout attack [n=136 (%)]
  OS RH IM GS NS FM Total
Sum of specialized department 64 (47.1) 15 (11.0) 11 (8.1) 9 (6.6) 2 (1.5) 2 (1.5) 103 (75.7)
Private clinic 43 (31.6) 2 (1.5) 6 (4.4) 6 (4.4) 1 (0.7) 2 (1.5) 60 (44.1)
General hospital 14 (10.3) 5 (3.7) 3 (2.2) 1 (0.7) 1 (0.7) 0 (0) 24 (17.6)
University hospital 7 (5.1) 8 (5.9) 2 (1.5) 2 (1.5) 0 (0) 0 (0) 19 (14.0)
Pharmacy - - - - - - 15 (11.0)
Oriental medical clinic - - - - - - 15 (11.0)
Acupuncture clinic - - - - - - 1 (0.7)
Others - - - - - - 2 (1.5)

FM: family medicine, GS: general surgery, IM: internal medicine, NS: neurosurgery, OS: orthopedics, RH: rheumatology.

Table 3.
Medical institute and specialized department for diagnosis of gout [n=136 (%)]
  OS RH IM GS NS FM PC RM NR Total
Sum of specialized department 59 (43.4) 29 (21.3) 12 (8.8) 3 (2.2) 1 (0.7) 3 (2.2) 1 (0.7) 1 (0.7) 8 (5.9) 117 (86.0)
Private clinic 29 (21.3) 2 (1.5) 11 (8.1) 2 (1.5) 1 (0.7) 3 (2.2) 1 (0.7) 1 (0.7) 2 (1.5) 52 (38.2)
General hospital 21 (15.4) 9 (6.6) 0 (0) 1 (0.7) 0 (0) 0 (0) 0 (0) 0 (0) 2 (1.5) 33 (24.3)
University hospital 9 (6.6) 18 (13.2) 1 (0.7) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 4 (2.9) 32 (23.5)
Pharmacy - - - - - - - - - 3 (2.2)
Oriental medical clinic - - - - - - - - - 4 (2.9)
Acupuncture clinic - - - - - - - - - 1 (0.7)
Others - - - - - - - - - 11 (8.1)

FM: family medicine, GS: general surgery, IM: internal medicine, NS: neurosurgery, NR: no response, OS: orthopedics, PC: pain clinic, RH: rheumatology, RM: rehabilitation medicine.

Table 4.
Method for the diagnosis of gout [n=136 (%)]
Blood test 95 (69.9)
X-ray 46 (33.8)
Physical examination only 25 (18.4)
Joint fluid analysis 14 (10.3)
Table 5.
Medical institute and specialized department for diagnosis of gout [n=136 (%)]
  OS RH IM GS NS FM PC RM NR Total
Sum of specialized department 47 (34.6) 22 (16.2) 11 (8.1) 6 (4.4) 1 (0.7) 2 (1.5) 5 (3.7) 2 (1.5) 1 (0.7) 97 (71.3)
Private clinic 30 (22.1) 8 (5.9) 7 (5.1) 3 (2.2) 1 (0.7) 1 (0.7) 3 (2.2) 1 (0.7) 0 (0) 54 (39.7)
General hospital 11 (8.1) 4 (2.9) 0 (0) 2 (1.5) 0 (0) 0 (0) 1 (0.7) 1 (0.7) 0 (0) 19 (14.0)
University hospital 6 (4.4) 10 (7.4) 4 (0) 1 (0.7) 0 (0) 1 (0.7) 1 (0.7) 0 (0) 1 (0.7) 24 (17.6)
Pharmacy - - - - - - - - - 4 (2.9)
Oriental medical clinic - - - - - - - - - 9 (6.6)
Acupuncture clinic - - - - - - - - - 4 (2.9)
Herbal medicine shop - - - - - - - - - 1 (0.7)
Others - - - - - - - - - 19 (14.0)

FM: family medicine, GS: general surgery, IM: internal medicine, NS: neurosurgery, NR: no response, OS: orthopedics, PC: pain clinic, RH: rheumatology, RM: rehabilitation medicine.

Table 6.
Treatment of joint pain in patients with gout
Treatment methods for joint pain (n, %)
  Oral medication 110 (80.9)
  Intra-muscular injection 53 (39.0)
  Physical therapy 50 (36.8)
  Acupuncture 26 (19.1)
  Intraarticular injection 20 (14.7)
  Herbal medication 11 (8.1)
  Moxibustion 9 (6.6)
  Others 2 (1.5)
Oral medication for joint pain (n, %)
  NSAID 76 (55.9)
  Allopurinol 52 (38.2)
  Colchicine 28 (20.6)
  Steroid 18 (13.2)
  Acetaminophen 11 (8.1)
  Unknown 47 (34.6)

NSAID: nonsteroidal antiinflammatory drug.

Table 7.
Characteristics of gout attack
Total numbers of gout attack (n, %)
  1∼10 83 (61.0)
  11∼20 9 (6.6)
  21∼30 5 (3.7)
  31∼50 6 (4.4)
  51∼100 2 (1.5)
  Over 100 1 (0.7)
  Unknown 30 (22.1)
Duration of joint pain during first gout attack (n, %)
  1∼5 days 60 (44.1)
  6∼10 days 44 (32.4)
  11∼20 days 10 (7.4)
  21∼30 days 3 (2.2)
  Over 30 days 3 (2.2)
  Unknown 16 (11.8)
Frequency of joint pain (n, %)
  Less than one per year 31 (22.8)
  2∼12 per year 59 (43.4)
  2∼4 per month 12 (8.8)
  2∼6 per week 3 (2.2)
  Every day 7 (5.1)
  No response 24 (17.6)
Pattern of gouty attack frequency (n, %)
  More frequently 59 (43.4)
  No change 40 (29.4)
  No response 37 (27.2)
Site of joint pain (n, %)
  First MTP 77 (56.6)
  Other MTP except first MTP 16 (11.8)
  Dorsum of foot 39 (28.7)
  Heel 12 (8.8)
  Ankle 48 (35.3)
  Knee 43 (31.6)
  Hand 11 (8.1)
  Wrist 22 (16.2)
  Elbow 7 (5.1)

MTP: metatarsophalangeal.

Table 8.
Pattern of oral medications in patients with gout
  Intermittent, if feel pain (n, %) Every day (n, %) No response (n, %)
NSAID 67 (49.3) 9 (6.6) 60 (44.1)
Allopurinol 24 (17.6) 28 (20.6) 84 (61.8)
Steroid 13 (9.6) 5 (3.7) 118 (86.8)
Colchicine 20 (14.7) 8 (5.9) 108 (79.4)
Acetaminophen 7 (5.1) 4 (2.9) 125 (9.19)
Unknown 33 (24.3) 14 (10.3) 89 (65.4)

NSAID: nonsteroidal antiinflammatory drug.

Table 9.
Questionnaire regarding patient's knowledge about gout (translated into English)
  Yes (n, %) No (n, %) No response (n, %)
I know the cause of gout 73 (53.7) 55 (40.4) 8 (5.9)
I know how to do the emergency care in gout attack 40 (29.4) 88 (64.7) 8 (5.9)
I know the difference between emergency care and maintenance therapy of gout 34 (25.0) 88 (64.7) 14 (10.3)
I know it is important to take the medicine daily for lowering the uric acid regardless of the pain 77 (56.6) 51 (37.5) 8 (5.9)
I know allopurinol or zyloric 41 (30.1) 89 (65.4) 7 (5.1)
I know the aggravating factors to development of gout 78 (57.4) 53 (39.0) 6 (4.4)
I heard explanation about gout from doctor 112 (82.4) 19 (14.0) 6 (4.4)
I read the information brochure about gout 59 (43.4) 72 (52.9) 6 (4.4)
I know the alcohol effects on gout 103 (75.7) 26 (19.1) 8 (5.9)
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