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Cheon, Lee, Mok, Kim, Park, Kim, Kim, Byun, Suh, Yoo, Kim, and Ko: A Case of Papillary Thyroid Carcinoma Combined with Metastatic Renal Cell Carcinoma in the Thyroid
Case Report
Journal of Korean Society of Endocrinology

Journal of Korean Society of Endocrinology 2006; 21(1): 85-89.

Published online: 20 February 2006

DOI: https://doi.org/10.3803/jkes.2006.21.1.85

A Case of Papillary Thyroid Carcinoma Combined with Metastatic Renal Cell Carcinoma in the Thyroid

Kang Il Cheon, Kyung Wook Lee, Ji Oh Mok, Yeo Ju Kim, Hyung Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo, Hee Kyung Kim1, Youn Woo Ko2

Department of Internal medicine, College of Medicine, Soonchunhyang University, Seoul, Korea.

1Department of Pathology, College of Medicine, Soonchunhyang University, Seoul, Korea.

2Department of Otorhinolaryngology, College of Medicine, Soonchunhyang University, Seoul, Korea.

Received 19 August 2005       Accepted 5 December 2005

Copyright © 2006 Korean Endocrine Society

Abstract

Metastasis to the thyroid from distant cancer is rarely diagnosed clinically and renal cell carcinoma is the most common group of neoplasm to metastasize to the thyroid. Papillary thyroid carcinoma is known as the most frequent primary thyroid cancer. But coexistence with metastatic renal cell carcinoma to thyroid and papillary thyroid carcinoma is very rare. We are reporting this highly unusual case of metastatic renal cell carcinoma to thyroid, which harbored papillary thyroid cancer. To our knowledge, this is the first case reported in Korea. A 57-year-old woman presented with hoarseness and palpable anterior neck mass. She had a history of renal cell carcinoma of right kidney, which had been resected 10 years previously and had undergone lower anterior resection due to sigmoid colon cancer 2 months before. Fine needle aspiration cytology suggested follicular neoplasm, and total thyroidectomy was performed. The pathology from the thyroid nodules showed papillary thyroid cancer combined metastatic renal cell carcinoma.

Keywords: Papillary thyroid cancer, Renal cell carcinoma, Metastasis

Figures and Tables

Fig. 1
Neck CT with contrast enhancement shows multiple solid nodules in both thyroid gland and diffuse goiter.
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Fig. 2
Gross appearance of the right thyroid gland. Several well-demarcated ovoid masses are noted, ranging from 0.4 × 0.4 to 1.2 × 1.0 cm. The cut surface is bright yellow and reddish brown.
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Fig. 3
(A) The white and fibrotic area in the left thyroid gland is composed of numerous true papilla with complex branching (H & E stain, × 40). (B) The tumor cells have optically clear nuclei and pseudoinclusions (arrow) (H & E stain, × 200).
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Fig. 4
The tumor cells have abundant clear cytoplasm and round nuclei and arranged in an alveolar structure by delicate vascular septa (H & E stain, × 400).
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Fig. 5
The normal thyroid tissue is positive for thyroglobulin (arrow) while the metastatic renal cell carcinoma is negative (IHC, × 100).
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