Journal List > J Korean Soc Endocrinol > v.21(3) > 1063866

Kim, Kim, Park, Park, Kang, Ahn, Cha, Lim, Kim, and Lee: A Case of Patient with Opioid-Induced Adrenocortical Insufficiency and Hypogonadism


Opioids are known to decrease plasma cortisol and testosterone level in human and other mammals. Nowadays, opioid use is exponentially increasing, but little is known about its side effects. With the help of progressive human science, we can habit longer life and as result, are becoming more avid for healthy life. In this respect, analgesics play important role in maintaining good and healthy quality of life. For this reason, it is important to fully understand its side effects and handle it with special precaution. We are reporting a 22-year-old male who had been taken opioid analgesic for more than six years to relieve chronic, intractable headache. Then, his hormone test revealed hypogonadotropic hypogonadism combined with hypoadrenocorticotropic hypoadrenalism but showed no definite clinical features except for sexual frigidity. After two years of oxycodon discontinuation, we reevaluated that his hormone test, and all other laboratory tests returned to the normal range.

Figures and Tables

Fig. 1
Brain MRI, sagital view, shows 12.7 mm sized pineal gland cyst.
Table 1
Initial combined pituitary function test

GH, growth hormone; FSH, follicular stimulating hormone; LH, luteinizing hormone, TSH, thyroid stimulating hormone.

Table 2
Combined pituitary function test after 2 years of oxycodon discontinuation

GH, growth hormone; FSH, follicular stimulating hormone; LH, luteinizing hormone, TSH, thyroid stimulating hormone.


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