Journal List > J Korean Diabetes Assoc > v.31(4) > 1062450

Choi: Peroxisome Proliferator Activated Receptor-δ (PPAR-δ)

Abstract

The development of novel treatments for the metabolic syndrome is imminent for decreasing the prevalence of type 2 diabetes and cardiovascular disease. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptor super-family of ligand-induced transcription factors. Among them, PPAR-α and PPAR-γ are therapeutic targets for dyslipidemia and insulin resistance. Recent studies have uncovered a dual benefit of PPAR-δ for both dyslipidemia and insulin resistance. Furthermore, PPAR-δ enhances fatty acid oxidation and energy uncoupling in adipose tissue and muscle. PPAR-δ activation seems to operate similarly to the caloric restriction and prolonged exercise. Combined effects of PPAR-δ make it a promising therapeutic target for the metabolic syndrome, and ongoing studies about PPAR-δ will improve our knowledge of the physiologic regulation of whole body energy metabolism.

Figures and Tables

Fig. 1
Effects of PPAR-δ in the metabolic syndrome.
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