Journal List > J Korean Diabetes Assoc > v.31(2) > 1062433

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Yu, Nam, Shim, Chung, Kim, Hong, and Kim: A Case of Fulminant Type 1 Diabetes Associated with Pregnancy
Case Report
The Journal of Korean Diabetes Association

The Journal of Korean Diabetes Association 2007; 31(2): 180-183.

Published online: 31 March 2007

DOI: https://doi.org/10.4093/jkda.2007.31.2.180

A Case of Fulminant Type 1 Diabetes Associated with Pregnancy

Hyung Kwon Yu, Moonsuk Nam, Wan Sub Shim, Hyun Jung Chung, Eun Joo Kim, Seong Bin Hong, Yong Seong Kim

Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Korea.

Received 4 September 2006       Accepted 30 January 2007

Copyright © 2007 Korean Diabetes Association

Abstract

Type 1 diabetes is characterized by insulin deficiency due to destruction of pancreatic β-cells. A novel subtype of type 1B which is rapidly developed without any evidence of autoimmunity has been recently proposed as fulminant type I diabetes. In female patients of child-bearing age, the onset of fulminant type 1 diabetes occurred frequently during pregnancy or after delivery in Japan, however, there was no report about fulminant type 1 diabetes associated with pregnancy in Korea. We report a case of fulminant type 1 diabetes associated with pregnancy.
A 28-year-old woman suffering from excessive thirst with vomiting and general weakness after four days from normal spontaneous vaginal delivery presented to our hospital. Laboratory examination revealed a high blood glucose level and evidence of diabetic ketoacidosis, butHbA1c level was normal. These findings suggested a very recent onset of diabetes mellitus. Serum C-peptide level was very low level. Antibodies to glutamic acid decarboxylase (GAD) was weakly positive. After fluid and insulin based management, patient successfully recovered without any serious complication.

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