Journal List > J Korean Diabetes Assoc > v.30(5) > 1062403

Yu, Song, Kim, Yim, Han, Park, Yoon, and Chung: Clinical Courses of Two Women with Gestational Diabetes Mellitus Who are GAD Antibody Positive

Abstract

Gestational diabetes mellitus (GDM) is defined as glucose intolerance of various degrees with onset or first recognition during pregnancy. Women with GDM are at high risk of developing type 2 diabetes later in life, but the risk of developing type 1 diabetes is also increased. Positivity for glutamic acid decarboxylase (GAD) antibodies during pregnancy confers a high risk for subsequent progression to type 1 diabetes. Here, we reported the two cases with GDM who were GAD antibody positive and progressed to type 1 diabetes with different time-courses. One woman with GDM progressed rapidly to classical type 1 diabetes while the other became slowly progressive IDDM (SPIDDM) [or latent autoimmune diabetes in adults (LADA)].

Figures and Tables

Fig. 1
Plasma glucose and insulin concentrations during 100 g oral glucose tolerance test (OGTT) at 25th weeks of pregnancy in two cases.
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Fig. 2
Plasma glucose and insulin concentrations during 75 g oral glucose tolerance test (OGTT) at postpartum 6 weeks in two cases.
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