Journal List > J Korean Diabetes Assoc > v.30(1) > 1062375

Shim, Do, Kim, Kim, Hur, Kang, Rhee, Ahn, Lim, Kim, Lee, and Cha: The long term effects of rosiglitazone on serum lipid concentration and body weight

Abstract

Background

Although rosiglitazone, an insulin sensitizer, is known to have beneficial effects on high density lipoprotein cholesterol (HDL-C) concentration and low density lipoprotein (LDL) particle size, it has adverse effects on the increment of total cholesterol (TC) and LDL cholesterol (LDL-C), and body weight in some studies. Such adverse effects of rosiglitazone on the serum lipid profiles and body weight seem to be attributed to the fact that most studies with rosiglitazone are limited to a short period of follow up. The aim of this study was to evaluate the long term effects of rosiglitazone on the serum lipid levels and body weight.

Materials and methods

We prospectively evaluated fasting serum glucose, HbA1c, TC, LDL-C, triglyceride, HDL-C and body weight at baseline and every three months after rosiglitazone usage (4 mg/d) in 202 type 2 diabetic patients.

Results

TC levels had increased maximally at 3 months and thereafter decreased, but were significantly higher at 18 months than those at baseline. LDL-C levels from the first 3 months to 12 months were significantly higher than those at baseline, but after 15 months, LDL-C concentration was not significantly different from the basal LDL-C concentration. HDL-C levels had increased after first 3 months and the increment of HDL-C concentration were maintained. The increment of HDL-C was more prominent in patients with low basal HDL-C concentration than in patients with high basal HDL-C concentration. Body weight from 3 months to 18 months were higher than that at baseline, but after 3 months, body weight did not increase furthermore significantly.

Conclusions

The adverse effects on lipid concentration and body weight of rosiglitazone may attenuate after long term usage of rosiglitazone.

Figures and Tables

Fig. 1
Changes of lipid profiles after rosiglitazone usage.
A. Change of total cholesterol concentration after rosiglitazone usage
B. Change of low density lipoprotein cholesterol concentration after rosiglitazone usage
C. Change of high density lipoprotein cholesterol concentration after rosiglitazone usage
D. Change of triglyceride concentration after rosiglitazone usage.
LDL-C, low-densitiy lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol;
*P<0.05 vs. baseline
P<0.05 vs. 3rd month
P<0.05 vs. 6th month
jkda-30-17-g001
Table 1
Changes of Body Weight, BMI, Fasting Glucose, Postprandial 2 Hour Glucose and HbA1c after Rosiglitazone Usage
jkda-30-17-i001

Data are expressed as means ±standard deviation

BMI, body mass index; PP, postprandial

*P<0.05 vs. baseline

Table 2
Changes of Lipid Profiles after Rosiglitazone Usag
jkda-30-17-i002

Data are expressed as means ±standard deviation

TC, total cholesterol;LDL, low-densitiy lipoprotein; HDL, high-density lipoprotein; TG, triglyceride; AIP, atherogenic index of plasma (log (Triglyceride/HDL-C))

*P<0.05 vs. baseline

P<0.05 vs. 3rd month

P<0.05 vs. 6th month

Table 3
The Change of Difference of Lipid Profiles after Rosiglitazone Usage
jkda-30-17-i003

Data are expressed as means ±standard deviation

TC, total cholesterol;LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol Delta TC: TC value at respective time minus TC value at baseline, Delta LDL-C: LDL-C value at respective time minus LDL-C value at baseline, Delta HDL-C: HDL-C value at respective time minus HDL-C value at baseline, Delta Triceride: Triglyceride value at respective time minus Triglyceride value at baseline,

*P<0.05 vs. 3rd month

Table 4
The Change of HDL-C and the Change of Difference of HDL-C According to the Basal HDL-C after Rosiglitazone Usage
jkda-30-17-i004

HDL-C, high-density lipoprotein cholesterol, Delta HDL-C: HDL-C value at respective time minus HDL-C value at baseline,

Group 1: HDL-C < 1.03 mmol/L in male, HDL-C < 1.29 mmol/L in female

Group 2: HDL-C ≥ 1.03 mmol/L in male, HDL-C ≥ 1.29 mmol/L in female

*P<0.05 group1 vs. group 2

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