The Associations between Alcohol Intake and HDL Cholesterol Subclasses in Korean Population

Jung Eun Lim; Jung Im Kim; Sun Ju Lee; Jae Woong Sull; Myoungsook Lee; Sun Ha Jee

doi:10.12997/jla.2012.1.2.61

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Lim, Kim, Lee, Sull, Lee, and Jee: The Associations between Alcohol Intake and HDL Cholesterol Subclasses in Korean Population

Original Article

Journal of Lipid and Atherosclerosis 2012; 1(2): 61-68.

Published online: 31 December 2012

DOI: https://doi.org/10.12997/jla.2012.1.2.61

The Associations between Alcohol Intake and HDL Cholesterol Subclasses in Korean Population

Jung Eun Lim¹, Jung Im Kim², Sun Ju Lee¹, Jae Woong Sull³, Myoungsook Lee², Sun Ha Jee¹

¹Department of Epidemiology and Health Promotion, Institute for Health, Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.

²Department of Food and Nutrition and Research Institute of Obesity Sciences, Sungshin Women's University, Seoul, Korea.

³Department of Bio-Medical Laboratory Science, Eulji University, Gyeonggi-do, Korea.

Corresponding Author: Sun Ha Jee, Department of Epidemiology and Health Promotion, Institute for Health, Promotion, Graduate School of Public Health, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea. Tel: +82-2-2228-1523, Fax: +82-2-365-5118, jsunha@yuhs.ac

Received 22 June 2012 Revised 24 July 2012 Accepted 25 July 2012

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective

Alcohol intake has been found to be associated with high-density lipoprotein (HDL) cholesterol. However, the association of alcohol intake with HDL cholesterol subclasses is unclear. Therefore, this study was conducted to determine the association between alcohol intake and HDL cholesterol subclasses among Koreans.

Methods

This study included in 1,101 healthy Koreans (men: 765, women: 336) who underwent health check-up at two hospitals in the Korean Cancer Prevention Study 2 (KCPS2). The amounts of alcohol intake were classified into 4 groups: non-, light, moderate, and heavy drinkers (0, <12.5, 12.5-49.9, and ≥50.0 g/day, respectively). The proportions of HDL cholesterol subclasses were measured after subclasses were identified by 4-30% gradient gel electrophoresis. Multiple regression models were used to estimate regression coefficients after multivariate adjustments.

Results

The concentration of HDL, HDL2 and HDL3 significantly increased with increasing amount of alcohol intake. After adjusted for age, body mass index (BMI), waist and smoking status, alcohol consumers of <12.5 g/day, 12.5-49.9 g/day and more than 50.0g/day showed significant positive associations with HDL, HDL2 and HDL3 concentration when compared to non-alcohol drinkers in men. In particular, The strongest positive associations were obtained with HDL2b and HDL3c.

Conclusion

HDL2 and HDL3 were significantly associated with increasing amount of alcohol intake in Koreans. In particular, HDL2b among HDL2 and HDL3c among HDL3 showed the strongest positive association with increasing amount of alcohol intake.

Keywords: HDL, HDL2, HDL3, Alcohol drinking

Figures and Tables

Fig. 1

HDL2b (mg/dL) differences according to age, BMI, waist and smoking status. All figures are adjusted for sex, age, BMI, waist and smoking status except relevant variable.

Table 1

The characteristics of the study population

HDL: high density lipoprotein, LDL: low-density lipoprotein.

103 participants in men and 155 participants in women have missing for alcohol intake

Mean±SD

Table 2

Correlations between high-density lipoprotein (HDL) subclasses levels and basic variables in men

Adjusted for age, BMI, waist and smoking status

HDL: high density lipoprotein, LDL: low-density lipoprotein

^*: P value <0.05

^†: P value <0.0001

Table 3

Correlations between high-density lipoprotein(HDL) subclasses levels and basic variables in women

Adjusted for age, BMI, waist and smoking status

HDL: high density lipoprotein, LDL: low-density lipoprotein

^*: P value <0.05

^†: P value <0.0001

Table 4

Regression analysis between alcohol intake and high-density lipoprotein (HDL) subclasses levels (mg/dL) in men

Adjusted for age, BMI, waist and smoking status

References

1. Taylor B, Irving HM, Baliunas D, Roerecke M, Patra J, Mohapatra S, Rehm J. Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis. Addiction. 2009; 104:1981–1990.

2. Arriola L, Martinez-Camblor P, Larrañaga N, Basterretxea M, Amiano P, Moreno-Iribas C, Carracedo R, Agudo A, Ardanaz E, Barricarte A, Buckland G, Cirera L, Chirlaque MD, Martinez C, Molina E, Navarro C, Quirós JR, Rodriguez L, Sanchez MJ, Tormo MJ, González CA, Dorronsoro M. Alcohol intake and the risk of coronary heart disease in the Spanish EPIC cohort study. Heart. 2010; 124–130.

3. Mukamal KJ, Chen CM, Rao SR, Breslow RA. Alcohol consumption and cardiovascular mortality among U.S. adults, 1987 to 2002. J Am Coll Cardiol. 2010; 55:1328–1335.

4. Calvert JW, Kevil CG, Spite MR. Regulation and maintenance of vascular tone and patency in cardiovascular health and disease. Int J Vasc Med. 2012; 396369.

5. Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, Willett W, Hennekens CH. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med. 1993; 329:1829–1834.

6. Savolainen MJ, Kesaniemi YA. Effects of alcohol on lipoproteins in relation to coronary heart disease. Curr Opin Lipidol. 1995; 6:243–250.

7. Moriguchi EH, Fusegawa Y, Tamachi H, Goto Y. Effects of smoking on HDL subfractions in myocardial infarction patients: effects on lecithin-cholesterol acyltransferase and hepatic lipase. Clin Chim Acta. 1991; 195:139–143.

8. Lee M, Jang Y, Kim K, Cho H, Jee SH, Park Y, Kim MK. Relationship between HDL3 subclasses and waist circumferences on the prevalence of metabolic syndrome: KMSRI-Seoul Study. Atherosclerosis. 2010; 213:288–293.

9. Wakabayashi I, Groschner K. Modification of the association between alcohol drinking and non-HDL cholesterol by gender. Clin Chim Acta. 2009; 404:154–159.

10. Gordon T, Ernst N, Fisher M, Rifkind BM. Alcohol and high-density lipoprotein cholesterol. Circulation. 1981; 64:III 63–III 67.

11. Hulley SB, Gordon S. Alcohol and high-density lipoprotein cholesterol: causal inference from diverse study designs. Circulation. 1981; 64:III 57–III 63.

12. Sillanaukee P, Koivula T, Jokela H, Myllyharju H, Seppä K. Relationship of alcohol consumption to changes in HDL-subfractions. Eur J Clin Invest. 1993; 23(8):486–491.

13. Bellocco R, Pasquali E, Rota M, Bagnardi V, Tramacere I, Scotti L, Pelucchi C, Boffetta P, Corrao G, La Vecchia C. Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis. Ann Oncol. 2012; 23:2235–2244.

14. Reynolds K, Lewis B, Nolen JD, Kinney GL, Sathya B, He J. Alcohol consumption and risk of stroke: a meta-analysis. JAMA. 2003; 289:579–588.

15. Schafer C, Parlesak A, Eckoldt J, Bode C, Bode JC, März W, Winkler K. Beyond HDL-cholesterol increase: phospholipid enrichment and shift from HDL3 to HDL2 in alcohol consumers. J Lipid Res. 2007; 48:1550–1558.

16. Williams PT, Krauss RM, Wood PD, Albers JJ, Dreon D, Ellsworth N. Associations of diet and alcohol intake with high-density lipoprotein subclasses. Metabolism. 1985; 34:524–530.

17. Mäkelä SM, Jauhiainen M, Ala-Korpela M, Metso J, Lehto TM, Savolainen MJ, Hannuksela ML. HDL2 of heavy alcohol drinkers enhances cholesterol efflux from raw macrophages via phospholipid-rich HDL2b particles. Alcohol Clin Exp Res. 2008; 32:991–1000.

18. Moore RD, Smith CR, Kwiterovich PO, Pearson TA. Effect of low-dose alcohol use versus abstention on apolipoproteins A-I and B. Am J Med. 1988; 84:884–890.

19. Hannuksela M, Marcel YL, Kesaniemi YA, Savolainen MJ. Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol. J Lipid Res. 1992; 33:737–744.

20. Lagrost L, Athias A, Herbeth B, Guyard-Dangremont V, Artur Y, Paille F, Gambert P, Lallemant C. Opposite effects of cholesteryl ester transfer protein and phospholipid transfer protein on the size distribution of plasma high density lipoproteins. Physiological relevance in alcoholic patients. J Biol Chem. 1996; 271:19058–19065.

21. Miller NE. Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis. Am Heart J. 1987; 113:589–597.

22. Bakogianni MC, Kalofoutis CA, Skenderi KI, Kalofoutis AT. Clinical evaluation of plasma high-density lipoprotein subfractions (HDL2, HDL3) in noninsulin-dependent diabetics with coronary artery disease. J Diabetes Complications. 2001; 15:265–269.

23. Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N Engl J Med. 1991; 325:373–381.

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