Analysis on saliva of head and neck cancer patients

Kyungyi Jeong; Haesoon Lim

doi:10.11149/jkaoh.2012.36.4.303

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Jeong and Lim: Analysis on saliva of head and neck cancer patients

Original Article

Journal of Korean Academy of Oral Health

Journal of Korean Academy of Oral Health 2012; 36(4): 303-308.

Published online: 28 December 2012

DOI: https://doi.org/10.11149/jkaoh.2012.36.4.303

Analysis on saliva of head and neck cancer patients

Kyungyi Jeong^2,³, Haesoon Lim^1,^2,³

¹Depatment of Dental Education, Chonnam National University School of Dentistry, Gwangju, Korea.

²Dental Science Research Institute, Chonnam National University School of Dentistry, Gwangju, Korea.

³Chonnam National University Hwasun Hospital, Dental Clinic, Hwasun, Korea.

Corresponding Author: Haesoon Lim. Chonnam National University Hwasun Hospital, Dental Clinic, 322 Seoyang-ro, Hwasun-eup, Hwasun 519-763, Korea. Tel: +82-61-379-8080, Fax: +82-61-379-7795, hs1964@jnu.ac.kr

Received 5 November 2012 Revised 30 November 2012 Accepted 12 December 2012

(open-access):

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives

This study is performed to evaluate the salivary secretion, salivary pH and cariogenic activity in head and neck cancer patients.

Methods

Thirty patients (26 male, 4 female) who had head and neck cancer and were treated with chemotherapy or radiotherapy, and 28 normal volunteers (9 male, 19 female) as a control were included. The mean age of the patients group and control group were 55.9 years and 51.6 years, respectively. The patients group was examined of salivary secretion, salivary pH, and cariogenic activity, and was compared with the control group.

Results

In comparison with the control group, salivary secretion, salivary pH and cariogenic activity were lower, significantly, in head and neck cancer patients (P<0.01). There are negative correlations between cariogenic activity and salivary secretion (r=-0.364, P<0.01), cariogenic activity and salivary pH (r=-0.534, P<0.01) in head and neck cancer patients, and cariogenic activity and salivary pH (r=-0.413, P<0.05) in the control group. There are positive correlations between salivary pH and salivary secretion (r=0.409, P<0.01) in head and neck cancer patients.

Conclusions

These results suggest that salivary secretion and salivary pH are reduced; cariogenic activity is increased in head and neck cancer patients. Such salivary factor and cariogenic activity can increase the possibility of induction of dental caries.

Keywords: Cariogenic activity, Head and neck cancer, pH, Unstimulated whole saliva

Figures and Tables

Table 1

Comparision of cariogenic activity head and neck cancer patients and normal people

Values are Mean±SD.

^*P<0.01, by Mann-Whitney test.

Table 2

Correlation between variables in head and neck cancer patients

^*P<0.01, by Spearman's correlation.

Table 3

Correlation between variables in normal group

^*P<0.01, by Spearman's correlation.

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