Journal List > J Korean Bone Joint Tumor Soc > v.19(1) > 1052036

Kim, Chung, Chung, Rhee, Kang, Bahk, and Shim: Oncologic Outcome of Chondrosarcomas

Abstract

Purpose

We evaluated oncologic outcomes of chondrosarcomas and analyzed the disease-free survival rate of chondrosarcomas according to the various factors.

Materials and Methods

We performed a retrospective study for the disease-free survival rate of 48 chondrosarcomas, 44 of which underwent surgical treatment and followed up more than 18 months since 1993, and in the remaining 4 cases, the patients died before 18 months after surgery. The vsariables were location, tumor volume, histologic grade, stage, age at presentation and treatment performed. The mean follow up period was 43.8 months (1–196 months).

Results

The overall disease-free survival rate was 77.1% at mean 43.8 month follow up. The 5 year- and 10 year disease-free survival rates were 64% and 58% respectively. The histologic grade, stage, age at presentation revealed statistical significance on disease-free survival. All 9 patients treated with extended curettage for grade 1 central chondrosarcomas revealed disease-free survival with excellent functional outcome.

Conclusion

The disease-free survival rate of chondrosarcomas mainly depended on histologic grade, stage and age at presentation. Local recurrence and distant metastasis also revealed statistically significant differences of disease-free survival rate. Comparing to wide resection, extended curettage for low-grade central chondrosarcomas in extremities were efficient methods with similar survival rate and less functional losses and complications.

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Figure 1.
The 5 year- and 10 year disease-free survival rates were 64% and 58% respectively.
jkbjts-19-9f1.tif
Figure 2.
The disease-free survival rates of patients with grade 1, 2 and 3 diseases were 80.0%, 37.2% and 0% respectively (p<0.001).
jkbjts-19-9f2.tif
Table 1.
Surgical Treatment Performed
Histological grade Surgical treatment performed No of patients
Grade 1 Intralesional extended curettage 9
  W/R & reconstruction 18
Grade 2 W/R & reconstruction 14
  Amputation 3
Grade 3 W/R & reconstruction 2
  Biopsy only 1
  Amputation 1
Total   48

W/R, wide resection.

Table 2.
Results of Statistical Analysis (Fisher Exact Test) for Correlation to Disease-Free Survival
Factors Groups p-value
Sex Male/Female 0.745
Age ≥50 yrs/<50 yrs 0.002
Location Pelvis/Non-pelvic 0.452
Tumor volume ≥50 cm3/<50 cm3 0.903
Histological grade 1/2/3 <0.001
Surgical stage I/II/III <0.001
Surgical margin Wide resection/IL curettage 0.227
Treatment performed Amputation/LSS 0.379
Local recurrence Yes/No <0.001
Distant metastasis Yes/No <0.001

yrs, years; IL, intralesional; LSS, Limb salvage surgery.

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