Chondrosarcoma Arising from Benign Bone Tumor due to Malignant Transformation

Wan-hyeong Cho; Won-Seok Song; Chang-Bae Kong; Yun-Suk Hong; Jung-Dong Lee; Dae-Geun Jeon

doi:10.5292/jkbjts.2011.17.1.17

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Cho, Song, Kong, Hong, Lee, and Jeon: Chondrosarcoma Arising from Benign Bone Tumor due to Malignant Transformation

Original Article

J Korean Bone Joint Tumor Soc 2011;17(1):17-22.

Published online: 7 January 2011

DOI: https://doi.org/10.5292/jkbjts.2011.17.1.17

Chondrosarcoma Arising from Benign Bone Tumor due to Malignant Transformation

Wan-hyeong Cho, Won-Seok Song, Chang-Bae Kong, Yun-Suk Hong, Jung-Dong Lee, Dae-Geun Jeon

Department of Orthopedic Surgery, Korea Cancer Center Hospital, Seoul, Korea

Correspondence to: Dae-Geun Jeon, M.D. Department of Orthopedic Surgery, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul 139-706, Korea TEL: +82-2-970-1242 FAX: +82-2-970-2403 E-mail: dgjeon@kcch.re.kr

Received 28 February 201116 May 2011 Accepted 30 May 2011

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose

We analyzed the oncological outcome and prognostic factor of the chondrosarcoma arising from benign bone tumor due to malignant transformation.

Materials and Methods

From April 1986 to April 2009, 18 cases were considered eligible. We analyzed retrospectively the patient's characteristics and prognostic factors that affect to the local recurrence and distant metastasis.

Results

As classified by primary benign bone tumor, 4 cases were solitary osteochondroma, 11 cases were multiple osteochondromatosis and 3 cases were multiple enchondromatosis. The mean followup period was 85 months. The 5-year disease free survival rate of 18 patients was 85.9%. Their overall MSTS score was 25.2 (84%). There were local recurrence in 3 cases and no distant metastasis. We found that tumor location and surgical margin affected to the prognosis significantly.

Conclusion

In secondary chondrosarcoma patients, the prognosis was good relatively and tumor location and surgical margin are important prognosis factor.

Keywords: chondrosarcoma, maliganant transformation, prognostic factor

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Figure 1.

Patient was a 30-year old man who was diagnosed as Oiller's disease. (A) Bone scan shows multiple irregular uptakes. (B) This MRI was taken just before incisional biopsy. On the T1W1 MRI image, there are mixed low-high SI on T2WI and heterogeneous enhancement in both hip bones and proximal femurs. (C) Preoperative radiograph shows osteolytic bony destruction of right acetabulum, ischium and superior pubic ramus. (D) This radiograph was eight months after curettage and bone cementation. The patients is alive with disease.

Table 1.

Patients’ Characteristics

No	Sex/Age	Diagnosis	Localization	Grade	Volume	Surgery	Recurrences	Metastasis	Follow-up	Last status
1	M/52	MO	Proximal tibia	1	39	M/E	No	No	20.6	CDF
2	M/57	MO	Distal femur	1	170	W/E	No	No	40.8	CDF
3	M/28	SO	Distal femur	1	66	M/E	No	No	42.1	CDF
4	F/39	MO	Pubis	1	811	I/E	Yes	No	42.4	NED
5	M/24	MO	Proximal tibia	1	193	W/E	No	No	43.6	CDF
6	M/35	SO	Proximal tibia	1	296	I/E	No	No	45.8	CDF
7	F/50	SO	Pubis	1	166	M/E	No	No	54.1	CDF
8	M/33	MO	Pubis	1	507	I/E	Yes	No	60.3	AWD
9	M/45	MO	Scapula	1	503	W/E	No	No	80.7	CDF
10	M/23	SO	Ilium	1	249	W/E	No	No	103.1	CDF
11	M/35	MO	1st metacarpal	1	42	Ray amputation	No	No	151.2	CDF
12	M/35	MO	Ilium	1	943	W/E	No	No	166.1	CDF
13	F/30	Maffuci syndrome	4th distal phalynx	1	42	Disarticulation	No	No	103.2	CDF
14	M/15	MO	Distal femur	2	1,377	W/E	No	No	57.7	CDF
15	M/30	Oiller's disease	Acetabulum	2	497	I/E	Yes	No	92.7	AWD
16	M/31	Oiller's disease	2nd metacarpal	2	12	Ray amputation	No	No	120.3	CDF
17	F/41	MO	Distal femur	1	111	W/E	No	No	145.1	CDF
18	F/23	MO	Distal femur	1	286	W/E	No	No	158.2	CDF

SO, solitary osteochondroma; MO, multiple osteochondroma; W/E, wide excision; M/E, marginal excision; I/E, intralesional excision; CDF, continuously disease free; NED, no evidence of disease; AWD, alive with disease.

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