The Authors Reply: Severe metabolic acidosis can generate detremental clinical effect such as cardiovascular depression and central nervous system dysfunction1). It also disturbe important key enzymes' activity2). The effect of bocarbonate therapy aimed at correcting the pH, however, is controversial. Bicarbonate therapy produced CO₂ and paradoxically lower the intracellular pH and cerebrospinal fluid pH3, 4). Bicarbonate infusion is associated with an increased blood lactate levels4). It might be also produce the volume expansion, hypernatremia and renbound alkalemia. The other buffer agents such as Carbicarb (Na₂CO₃ + NaHCO₃) and THAM (Tris-hydroxymethyl aminomethane) are available, but these agents dose not imporving outcomes of metabolic acidosis4).