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Abstract
Periodontal disease is a bacterially caused by disease. To remove plaque and bacteria, it has been necessary to prescribe chemical drug to patient to subjugate therapeutic unvalue by mechanical scaling.
As a patient on a high dosage of the antibiotics to maintain the effective concentration may produce unfavorable side effects, this decase demands the Slow-release local drug delivery system.
The object of the experiment is to study on the slow-release local drug delivery effects of calcium sulfate compounded with tetracycline that mainly used in periodontal disease.
Experimental groups were divided into four classes as follow:
Group 1 : 10% tetracycline compounded modified calcium sulfate paste.
Group 2 : compounded and hardened 10% tetracycline and calcium sulfate.
Group 3 : compounded 10% tetracycline and calcium sulfate, used just before hardened.
Group 4 : tetracycline-ethylene vinyl acetate fiber.
In the four groups, release concentration, it's durability and the period of absorption by times are observed and concluded as follow:
An effective concentration(4µm/ml) remained until 5 weeks in group 1, 9 days in group 2, 7 days in group 3, 15 days in group 4.
It was fully fused at 11.8 days average in group 2 and 14.8 days average in group 3.
There were no statistically significant results in tetracycline concentration until a week in group 2 and 3(p<0.05)
These results suggest that tetracycline loaded calcium sulfate release sufficient tetracycline and fused in 11~14 days, so calcium sulfate is useful carrier as slow release local drug delivery system
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