Multiple dermatofibromas have been reported in patients with various autoimmune disorders such as systemic lupus erythematosus in receiving immunosuppressive therapy. We report a case of systemic lupus erythematosus in a 30-year-old woman who developed 23 dermatofibromas while she was treated with systemic corticosteroid. The mechanism for the development of multiple dermatofibromas in the setting of immune disturbance remains unclear. The altered immune system may play a role in the pathogenesis of this cutaneous condition.