Randomized Controlled Trial for Preventing Stomatitis and Discomfort among Acute Leukemic Patients

Chi Eun Song; Hyang Sook So; Deok Ju; Eun Jeong Kim

doi:10.5388/jkon.2011.11.1.33

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Song, So, Ju, and Kim: Randomized Controlled Trial for Preventing Stomatitis and Discomfort among Acute Leukemic Patients

Original Article

Journal of Korean Oncology Nursing

Journal of Korean Oncology Nursing 2011; 11(1): 33-40.

Published online: 14 March 2011

DOI: https://doi.org/10.5388/jkon.2011.11.1.33

Randomized Controlled Trial for Preventing Stomatitis and Discomfort among Acute Leukemic Patients

Chi Eun Song¹, Hyang Sook So², Deok Ju³, Eun Jeong Kim⁴

¹Nurse, Chonnam National University Hwasun Hospital, Hwasun, Korea.

²Professor, College of Nursing, Chonnam National University, Gwangju, Korea.

³Head Nurse, Chonnam National University Hwasun Hospital, Hwasun, Korea.

⁴Nurse, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Address reprint requests to: So, Hyang Sook. College of Nursing, Chonnam National University, 5 Hak-dong, Dong-gu, Gwangju 501-746, Korea. Tel: 82-62-220-4352, Fax: 82-62-227-4009, hsso@chonnam.ac.kr

Received 17 November 2010 Accepted 12 January 2011

Abstract

Purpose

This study compared the effect of two oral care agents on preventing stomatitis and discomfort for acute leukemic patients.

Methods

A total of forty patients was enrolled and randomly assigned to sodium bicarbonate or chlorhexidine group. WHO oral toxicity scale was used for measuring stomatitis and Beck's subjective oral discomfort scale for evaluating oral comfort. Data was collected from August 2009 to February 2010. The data was analyzed using Chi-square test, Fisher's exact test, and Mann-Whitney test.

Results

Data analyzed was thirty five one. The incidence of stomatitis was 47.4%, 68.8% in sodium bicarbonate and chlohexidine group respectively. The onset of stomatitis was about the 10th and 9th day after chemotherapy initiation, and the duration was 8.0 and 8.67 day respectively. The severity of stomatitis was highest on the 21st day after chemotherapy initiation. There were no statistical differences in the status of stomatitis and the levels of oral comfort during treatment periods.

Conclusion

Nurses should routinely assess oral cavity and encourage patients to do oral care actively from second to third week after chemotherapy initiation. Also sodium bicarbonate agent can be recommended to for preventing stomatitis.

Keywords: Randomized Controlled Trial, Stomatitis

Figures and Tables

Fig. 1

Status of oral comfort by treatment periods.

Table 1

Homogeneity test for general and clinical characteristics of subjects

AML, Acute Myeloid Leukemia; FLAG, Fludarabine, Cytarabine, G-CSF; ALL, Acute Lymphoblastic Leukemia; VPDL, Vincristine, Prednisolone, Daunorubicin, Leunase. ( - ) Fisher exact probability test.

Table 2

Difference of oral mucositis over WHO grade 2 by periods between two groups.

( - ) Fisher exact probability test.

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