Journal List > J Rhinol > v.23(2) > 1044374

Park, Song, Joo, Kim, Yun, Yoo, Hong, and Lee: The Relationship between Obstructive Sleep Apnea and Metabolic Syndrome in Adult

Abstract

Background and Objectives

The prevalence of obstructive sleep apnea (OSA) and metabolic syndrome (MS) is increasing and those have been recognized as potential risk factors for cardiovascular disease in adults. The aim of this study is to investigate the association between obstructive sleep apnea syndrome and metabolic syndrome.

Materials and Method

We enrolled 127 adults who were evaluated as having OSA. Each subject underwent overnight polysomnography to identify OSA based on the apnea-hypopnea index (AHI); OSA was diagnosed when AHI≥5, and subjects with AHI<5 were classified as the control group. MS was defined according to the Adult Treatment Panel (ATP) III criteria.

Results

Among 127 participants, 105 subjects were diagnosed with OSA. The mean age and smoker percentage showed differences between the OSA and control group. The prevalence of MS was significantly higher in the OSA group compared to the control group. As the severity of OSA increases, the prevalence of MS also increase.

Conclusion

The MS is significantly related to the OSA in adults. Therefore, we suggest that patient with OSA should be screened to identify the presence of MS.

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Table 1.
Comparison of demographic characteristics patients with OSA and Simple snoring
  Simple snoring (n=22) OSA (n=105) p value
Age (year) 41.95±14.24 43.92±10.63 0.035
Sex (Male: female) 16: 60 91: 14 0.115
Smoking (current, non) 08: 14 42: 63 0.814
Alcohol (current, ex, non) 13: 0: 9 79: 4: 22 0.092
BMI (kg/m2) 25.3±3.18 27.34±3.850 0.441

Data are presented as means± SD or n (%). BMI: body mass index, OSA: obstructive sleep apnea

Table 2.
Comparison of components of metabolic syndrome between patients with OSA and Simple snoring
  Simple snoring (n=22) OSA (n=105) p value
Glucose (mg/dL) 093.36±11.21 101.40±21.38 0.157
HDL Cholesterol (mg/dL) 050.38±12.68 044.99±10.10 0.108
Triglycerides (mg/dL) 126.85±59.4 188.29±144.01 0.149
Systolic blood pressure (mmHg) 123.77±10.36 129.60±14.71 0.105
Diastolic blood pressure (mmHg) 077.27±11.15 085.73±12.22 0.007
Waist circumference (cm) 087.39±10.08 093.63±9.93 0.032
Metabolic score 001.68±1.21 002.55±1.42 0.026

Data were presented as means± SD. All data were adjusted for age and smoking. OSA: obstructive sleep apnea, HDL: high-density lipoprotein

Table 3.
Prevalence of metabolic syndrome in obstructive sleep apnea
  Metabolic syndrome (%) OR (95% CI) p-value
Simple snoring (n=22) 04 (18.2) 1
Mild OSA (n=28) 08 (28.6) 1.80 (0.463–7.004)0 0.396
Moderate OSA (n=22) 13 (59.1) 6.50 (1.640–25.759) 0.008
Severe OSA (n=55) 35 (63.6) 7.88 (2.337–26.534) 0.001

Data were presented as n (%) or odds rations (OR) and 95% confidence intervals from multiple logistic regression analysis adjusting for age and smoking. OSA: obstructive sleep apnea, OR: odd ratio

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