Journal List > J Korean Ophthalmol Soc > v.53(9) > 1009165

Park and Rho: Short-Term Visual Outcomes According to Patterns of Macular Edema in Retinal Vein Occlusion Patients

Abstract

Purpose

To study the short-term visual outcomes affected by the patterns of macular edema in retinal vein occlusion patients.

Methods

In a retrospective study, 33 eyes of 33 consecutive patients with macular edema from retinal vein occlusion received an intravitreal injection of bevacizumab. Macular edema was classified according to OCT patterns and the effect on visual outcome evaluated: Diffuse macular edema (DME) vs. focal macular edema (FME), and macular edema with serous retinal detachment (SRD) vs. macular edema without serous retinal detachment (non-SRD).

Results

Nine patients had CRVO, 24 patients had BRVO and the follow-up period was 3.6 months. In the FME group, the mean baseline BCVA was 0.61 ± 0.34 and the final BCVA was 0.26 ± 0.29, a difference that was statistically significant (p < 0.01). In the DME group, the mean baseline BCVA was 0.85 ± 0.44 and the final BCVA was 0.73 ± 0.37, a difference that was not statistically significant (p = 0.07). In the non-SRD group, the mean baseline BCVA was 0.76 ± 0.43 and the final BCVA was 0.38 ± 0.36, a difference that was statistically significant (p < 0.01). In the SRD group, the mean baseline BCVA was 0.73 ± 0.40 and the final BCVA was 0.64 ± 0.42, a difference that was not statistically significant (p = 0.07).

Conclusions

Visual outcome was significantly better in the FME and non-SRD groups. The patterns of macular edema measured according to OCT were a prognostic factor for visual outcome.

Figures and Tables

Figure 1
The classification of macular edema in retinal vein occlusion on spectral-domain optical coherent tomographic images. (A) Diffuse thickening of the whole retinal layer (DME group). (B) Focal thickening of the retina (FME group).
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Figure 2
The classification of macular edema in retinal vein occlusion on spectral-domain optical coherence tomographic images. (A) Macular edema with serous retinal detachment (SRD group). (B) Macular edema without serous retinal detachment (Non-SRD group).
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Figure 3
Changes in visual acuity of DME group and FME group in patients with macular edema associated with retinal vein occlusion. DME = diffuse macular edema; FME = focal macular edema; BCVA = best corrected visual acuity; log MAR = logarithm of the minimal angle of resolution. p < 0.05 by Wilcoxon signed rank test was considered to be significant.
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Figure 4
Changes in visual acuity of SRD group and Non-SRD group in patients with macular edema associated with retinal vein occlusion. SRD = macular edema with serous retinal detachment; Non-SRD = macular edema without serous retinal detachment; BCVA = best corrected visual acuity; log MAR = logarithm of the minimal angle of resolution. p < 0.05 by Wilcoxon signed rank test was considered to be significant.
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Table 1
Characteristics of retinal vein occlusion patients treated with intravitreal bevacizumab injection
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Values are presented as mean ± SD unless otherwise indicated.

log MAR = logarithm of the minimal angle of resolution.

Table 2
Characteristics of retinal vein occlusion patients with macular edema divided into two groups by macular edema patterns (DME group vs FME group)
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Values are presented as mean ± SD unless otherwise indicated.

DME = diffuse macular edema; FME = focal macular edema; log MAR = logarithm of the minimal angle of resolution.

*Chai-square test; Mann-Whitney test; p < 0.05 was considered to be significant.

Table 3
Characteristics of retinal vein occlusion patients with macular edema divided into two groups by the presence of serous retinal detachment (SRD group vs Non-SRD group)
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Values are presented as mean ± SD unless otherwise indicated.

SRD = macular edema with serous retinal detachment; Non-SRD = macular edema without serous retinal detachment; log MAR = logarithm of the minimal angle of resolution.

*Chai-square test; Mann-Whitney test.

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