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Abstract
Purpose
To analyze the hyperacuity defects by preferential hyperacuity perimeter (PHP) in exudative age-related macular degeneration (AMD) and correlate them with the properties of pigment epithelial detachment (PED) obtained by optical coherence tomography (OCT).
Methods
Thirty eyes with exudative AMD with choroidal neovascularization (CNV) diagnosed by fluorescein angiography underwent PHP for hyperacuity defect and OCT for PED length and height. We compared hyperacuity defect with the shape of the PED by OCT.
Results
26 eyes with exudative AMD with CNV tested positive for hyperacuity defects. The size of the hyperacuity defect by PHP and the PED length by OCT showed positive correlation (p=0.010). In the 4 eyes that tested negative for hyperacuity defects, the PED was not high although the size was large.
References
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Figure 1.
Positive correlation between pigment epithelial detachment length and preferential hyperacuity perimeter defect size (Pearson's r=0.496, p=0.010).
Figure 2.
A 73-year-old man. In fluorescein angiography and OCT, pigment epithelial detachment is 3399 µm in length and 490 µm in height. Preferential hyperacuity perimeter test shows positive hyperacuity defects and the longest defect size is 4200 µm.
Figure 3.
A 68-year-old man. In fluorescein angiography and OCT, retinal pigment epithelial detachment is minimal. In OCT, elevation length is 1503 µm and elevation height is 102 µm. Preferential hyperacuity perimeter test shows no hyperacuity defect.
Figure 4.
Preferential hyperacuity perimeter height is significantly higher in the postive hyperacuity defect group than in the negative group (p=0.000).
Table 1.
The size of pigment epithelial detachment and preferential hyperacuity perimeter defect
| Case No. | Sex/Age | PED* Height (µm) | PED Length (µm) | PHP† defect size (µm) |
|---|---|---|---|---|
| 1 | M/71 | 630 | 2318 | 4200 |
| 2 | M/70 | 207 | 738 | 2100 |
| 3 | M/80 | 257 | 1476 | 3150 |
| 4 | F/82 | 163 | 706 | 1050 |
| 5 | F/55 | 132 | 2993 | 4200 |
| 6 | M/54 | 173 | 632 | 1050 |
| 7 | F/77 | 224 | 1092 | 1050 |
| 8 | M/73 | 490 | 3399 | 4200 |
| 9 | F/82 | 307 | 1496 | 1050 |
| 10 | F/68 | 157 | 2766 | 1050 |
| 11 | F/72 | 301 | 1243 | 4200 |
| 12 | M/81 | 348 | 2307 | 0 |
| 13 | M/59 | 390 | 2494 | 4200 |
| 14 | M/55 | 157 | 1913 | 1050 |
| 15 | M/71 | 124 | 930 | 0 |
| 16 | M/82 | 456 | 3750 | 4200 |
| 17 | M/59 | 162 | 802 | 2100 |
| 18 | M/70 | 684 | 2011 | 4200 |
| 19 | F/73 | 163 | 1721 | 0 |
| 20 | F/58 | 250 | 703 | 1050 |
| 21 | F/82 | 357 | 2144 | 4200 |
| 22 | M/68 | 603 | 2091 | 3150 |
| 23 | F/72 | 550 | 687 | 3150 |
| 24 | M/56 | 428 | 704 | 4200 |
| 25 | M/55 | 211 | 610 | 1050 |
| 26 | F/70 | 273 | 984 | 1050 |
| 27 | M/57 | 290 | 3035 | 4200 |
| 28 | M/70 | 157 | 3642 | 2100 |
| 29 | M/68 | 102 | 1503 | 0 |
| 30 | F/77 | 427 | 857 | 2100 |
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