Journal List > J Korean Ophthalmol Soc > v.50(1) > 1008367

Seo, Park, and Chung: Analysis of Retinal Nerve Fiber Layer Thickness in Patients With Superior Segmental Optic Hypoplasia

Abstract

Purpose

To analyze the thickness of the peripapillary retinal nerve fiber layer (RNFL) in patients with superior segmental optic hypoplasia (SSOH) using optical coherence tomography (OCT).

Methods

Ten eyes of 10 patients with SSOH and 20 eyes of 20 subjects as normal control were evaluated. The peripapillary RNFL thickness measured by Stratus OCT was compared between the two groups.

Results

The mean RNFL thickness was significantly different between SSOH patients (72.35±14.77 µ m) and normal subjects (111.61±6.62 µ m) (p<0.001). The extent to which the RNFL thickness was below 5 percentile of normal subjects on the TSNIT graph was from the 41.7±15.53 to 110.1±7.47 scan number, which corresponded mainly with the superior nasal region. Moreover, in a clock‐ hour analysis, the peripapillary RNFL thickness of the SSOH patients decreased significantly from 10 o'clock to 6 o'clock compared to normal subjects (p<0.01).

Conclusions

Peripapillary RNFL thickness in patients with SSOH was reduced in the superior, nasal, and inferior regions. Further studies involving larger populations of patients should be performed to verify these findings.

References

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Figure 1.
The right eye with superior segmental optic hypoplasia. Representative color disc photograph (A) and retinal nerve fiber layer (RNFL) photograph (B) showing neuroretinal rim thinning in the superior nasal region with corresponding RNFL defects. (C) Humphrey automated perimetry shows a characteristic inferior visual field defect. (D) Optical coherence tomography (OCT) scan shows the peripapillary RNFL thinning in superior region of the right eye.
jkos-50-139f1.tif
Figure 2.
The peripapillary retinal nerve fiber layer (RNFL) thickness assessed by optical coherence tomography is shown for clock hour around optic nerve head. Open squares represent mean RNFL thickness from 20 eyes of normal subjects, and solid squares from 10 eyes with superior segmental optic hypoplasia (SSOH). Error bars indicate 1 standard deviation from the mean. Asterisks indicate a significant difference of RNFL thickness between normal subjects and SSOH (p<0.01).
jkos-50-139f2.tif
Table 1.
Demographics of the study eyes
SSOH Control P value
Patients No. (eyes) 10 (10) 20 (20)
Gender (male:female) 3:7 8:12
Age (years) 44.3±14.6 (17~64) 41.8±22.4 (21~65) 0.948
SE (diopter) -3.35±2.60 -3.15±2.85 0.920

SSOH=superior segmental optic hypoplasia

SE=spherical equivalent

Mann-Whitney U test

Table 2.
Clinical characteristics of superior segmental optic hypoplasia
Visual acuity 20/20 Ophthalmoscopic findings
Family history - Superior entrance of CRA 9
Maternal DM - Superior scleral halo 6
Visual field Thinning of superior RNFL 10
MD (decibel) -4.18±2.57 Thinning of inferior RNFL 5
PSD (decibel) 5.51±4.31 Previous diagnosis
Disc mapping SN> ST§ > NΠ Normal tension glaucoma 6
Optic neuritis 1

MD=mean deviation

PSD=pattern standard deviation

SN=superonasal

§ ST=superotemporal

Π N=nasal

CRA=central retinal artery.

Table 3.
The peripapillary RNFL thickness (µm) in eyes with SSOH and normal controls
Average Quadrants
Superior Nasal Inferior Temporal
SSOH 72.35±14.77 57.90±19.19 49.50±11.36 108.00±30.57 74.00±11.44
Normal 111.61±6.62 135.45±6.03 85.75±17.67 142.60±9.76 82.50±8.86
P value <0.001 <0.001 <0.001 <0.001 0.074
∆ (µm)§ 39.26 77.55 36.25 34.60 8.50

RNFL=retinal nerve fiber layer; RNFL thickness between SSOH and normal controls

SSOH=superior segmental optic hypoplasia

Mann-Whitney U test

§ ∆=difference of RNFL thickness between SSOH and normal controls.

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