Journal List > Korean J Urol > v.48(1) > 1004962

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Kim, Yae, Kim, Kwon, and Chung: Clinical Experience of 27 Pediatric Renal Transplantation at a Single Center
Original Article
Korean Journal of Urology

Korean Journal of Urology 2007; 48(1): 72-76.

Published online: 31 January 2007

DOI: https://doi.org/10.4111/kju.2007.48.1.72

Clinical Experience of 27 Pediatric Renal Transplantation at a Single Center

Ki Ho Kim, Suk Jun Yae, Jae Su Kim, Tae Gyun Kwon, Sung Kwang Chung

Department of Urology, College of Medicine, Kyungpook National University, Daegu, Korea.

Corresponding author (skchung@knu.ac.kr)

Received 3 July 2006       Accepted 7 December 2006

Copyright © 2007 The Korean Urological Association

Abstract

Purpose

Renal transplantation is considered the treatment of choice for children with end-stage renal disease (ESRD). The results of renal transplantation were retrospectively analyzed to assess certain aspects of pediatric renal transplantation.

Materials and Methods

Between January 1989 and January 2005, 27 pediatric kidney transplantations were carried out at our center. Fifteen (55.5%) patients underwent hemodialysis, two (7.4%) peritoneal dialysis and ten (37.0%) were conservative managed prior to treatment. Living-related donors provided 25 (92.6%) of the transplanted organs, with cadaver sources utilized for 2 (7.4%) patients. The donor age, organ source, etiology of ESRD, hospitalization period, postoperative complications, occurrence and number of acute rejections, and graft survival were assessed.

Results

The causes of renal failure were chronic glomerulonephritis in 10 patients [IgA 3 nephropathy, 3 membranoproliferative glomerulonephritis (MPGN), 2 nephrotic syndrome and 2 focal segmental glomerulosclerosis (FSGS)], urinary tract anomalies in 6 (4 reflux nephropathy and 2 polycystic kidney), Alport syndrome in 1, hypertensive nephropathy in 2, systemic immunological disease in 1 and unknown causes in a further 5. Acute rejection occurred in 12 patients, all of who recovered after steroid pulse therapy. Growth and development failed in 2 patients. The postoperative complications included 4 urinary tract infections, 3 retroperitoneal hematomas, 2 lymphoceles and 1 acute ureteral obstruction. Four patients expired due to post-operative complications, such as disseminated intravascular coagulation (DIC), intracranial hematoma, sepsis and renal failure.

Conclusions

Pediatric renal transplantation can be successful, even in young children with ESRD.

Keywords: Kidney transplantation, Children

Figures and Tables

Fig. 1
(A) Graft survival, (B) Patient survival.
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Table 1
Patient pre-transplantation characteristics
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Table 2
Etiology of the ESRD in the transplanted children
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ESRD: end-stage renal disease, MPGN: membranoproliferative glomerulonephritis, FSGS: focal segmental glomerulosclerosis

Table 3
Causes of graft failures
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Table 4
Post-transplant complications
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ORCID iDs

Tae Gyun Kwon
https://orcid.org/http://orcid.org/0000-0002-4390-0952

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