Journal List > J Korean Rheum Assoc > v.14(4) > 1003587

Won, Han, Park, and Ahn: A Case of Wegener's Granulomatosis with Colitis

Abstract

Wegener's granulomatosis is an uncommon disease that is characterized by granulomatous necrotizing vasculitis affecting small vessels. It typically targets the upper and lower respiratory tract and the kidney, but gastrointestinal involvement is rare. A 41-year-old man who has been already diagnosed with Wegener's granulomatosis by nasal cavity biopsy was admitted with bloody diarrhea and high fever. He had discontinued taking the immunosuppressive medication. His colonoscopic finding revealed colitis and ulcer lesions which biopsies show vasculitis and ill-defined granuloma. Therefore he was treated with systemic steroid and improved dramatically.

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Fig. 1.
There were several ulcerative lesions with peripheral mucosal edema and petechiae in the ileocecal valve (A) and colon (B).
jkra-14-375f1.tif
Fig. 2.
(A) Chronic vasculitis with intravascular neutrophilic thrombi (arrow) in lamina propria on the ileocecal valve (H&E stain x100). (B) Ulcer with ill-defined granulomas (arrows) on the colon (H&E stain x200).
jkra-14-375f2.tif
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