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Han: Is Triglyceride Atherogenic?
Review Article
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2009; 24(3): 151-155.

Published online: 30 September 2009

DOI: https://doi.org/10.3803/jkes.2009.24.3.151

Is Triglyceride Atherogenic?

Ki Hoon Han

Division of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea.

Copyright © 2009 Korean Endocrine Society

Figures and Tables

Fig. 1
The role of adipose tissue in triglyceride metabolism.
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Fig. 2
The role of hepatocytes in triglyceride synthesis[1].
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Fig. 3
The change of lipid metabolism under condition of insulin resistance (IR).
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Fig. 4
The possible mechanism of triglyceride-rich lipoprotein (TRL) particles to induce atherosclerosis[4].
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Fig. 5
The distribution of apoB100 and apoB48-containing particles in the atherogenic arterial wall[5].
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Fig. 6
Triglycerides and CHD risk[8].
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References

1. Davidson MH. Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids. Am J Cardiol. 2006. 98:27i–33i.
2. Hussain MM, Bakillah A. New approaches to target microsomal triglyceride transfer protein. Curr Opin Lipidol. 2008. 19:572–578.
3. Iqbal J, Hussain MM. Intestinal lipid absorption. Am J Physiol Endocrinol Metab. 2009. 296:E1183–E1194.
4. Proctor SD, Vine DF, Mamo JC. Arterial retention of apolipoprotein B(48)- and B(100)-containing lipoproteins in atherogenesis. Curr Opin Lipidol. 2002. 13:461–470.
5. Proctor SD, Mamo JC. Intimal retention of cholesterol derived from apolipoprotein B100- and apolipoprotein B48-containing lipoproteins in carotid arteries of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol. 2003. 23:1595–1600.
6. Dominiczak MH. Hyperlipidaemia and cardiovascular disease: nonfasting triglycerides gain momentum--but nothing changes on the metabolic syndrome front. Curr Opin Lipidol. 2008. 19:326–327.
7. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007. 298:299–308.
8. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt SM, Khaw KT, Gudnason V. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007. 115:450–458.
9. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007. 298:309–316.
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