Journal List > J Korean Endocr Soc > v.21(6) > 1003326

Oh: Glucagon-like Peptide-1 Analogue and Dipeptidyl Peptidase-IV Inhibitors

Figures and Tables

Fig 1
Amino acid sequence of GLP-1 and incretin mimetics under development as antidiatetic drugs. Amino acids identical to the same position in the GLP-1 sequence are shown in light grey, amino acids different from the native molecule are displayed in darker grey.
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Fig. 2
Structures of DPP-IV inhibitors.
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Fig. 3
HbA1c concentrations during 12 weeks (core study, open symbols) and 1 year (extension study, closed symbols) treatment of type 2 diabetic patients with metformin alone (circles) or in combination with vildagliptin (50 mg once daily; triangles)[44].
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Fig. 4
Means ± SE time courses of insulin secretion (pmol/L 30 min)/(mmol/L) (A), dynamic insulin sensitivity (OGIS, mL · min · -1 · m-2) (B), and adaptation index (nmolC-peptide mmolglucose-1 mL-1 · m-2) (C) at baseline (week 0) and after 12, 24, and 52 weeks of treatment with vildagliptin (50 mg once daily, n = 31) or placebo (n = 26) in metformin-treated type 2 diabetic subjects. D: Regression between change in adaptation index and change in A1C after 52 weeks of treatment with vildagliptin (●) or placebo (○). Asterisks indicate probability level of random difference between groups. *P < 0.05; **P < 0.01[45].
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Table 1
Actions of GLP-1
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Table 2
Comparison of dipeptidyl peptidase-IV (DPP-IV) antagonists with glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-1 agonists[51]
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