Journal List > J Korean Acad Nurs > v.45(4) > 1003100

Baek and Yi: Factors Influencing Quality of Life during Chemotherapy for Colorectal Cancer Patients in South Korea



The purpose of this study was to investigate the levels of physical symptoms, anxiety, depression, and quality of life (QOL) during chemotherapy for colorectal cancer patients in South Korea and to identify factors influencing their QOL.


Data were collected from 144 colorectal cancer patients receiving chemotherapy during 2012 at one general hospital located in Seoul. Physical symptoms were measured by the M. D. Anderson Symptom Inventory-Gastrointestinal Cancer Module, and anxiety and depression were measured by the Hospital Anxiety Depression Scale. QOL was measured by the Functional Assessment of Cancer Therapy-Colorectal. Data were analyzed using descriptive statistics, t-test, one-way ANOVA, Scheffé post hoc test, Pearson correlation and stepwise multiple regression.


Mean age of the participants was 56.6 and most of them were not employed. In terms of cancer stage, 38.2% were in stage 3, followed by stage 4 (34.7%). The most frequent symptom was lack of appetite, followed by sleep disturbance and fatigue. The mean score for anxiety was 5.40 with a prevalence of 23% and that of depression 8.85 with a prevalence of 64.6%. The mean score for quality of life was 81.93 out of 136 and 75.3% of the variance in QOL was explained by depression, symptoms, anxiety, treatment place, and occupational status. Depression was the strongest predictive factor.


Oncology professionals need to pay special attention to relieving depression as well as physical symptoms to improve QOL during chemotherapy for colorectal cancer patients.

Figures and Tables

Table 1

Sociodemographic Characteristics of the Participants (N=144)

Table 2

Disease-related Characteristics of the Participants (N=144)


Op=Operation; RT=Radiation therapy.

Table 3

Scores of Symptoms and Disturbance (N=144)


*Between 5 and 6 on a 0~10 scale; 7 or greater on a 0~10 scale.

Table 4

Scores of Anxiety, Depression and Quality of Life (N=144)

Table 5

Factors Influencing Quality of Life (N=144)



This manuscript is based on the part of the first author's master's thesis from Seoul National University.


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