Journal List > Korean Diabetes J > v.33(2) > 1002347

Ahn: Insulin Resistance During Pregnancy

Abstract

Pregnancy is a complex metabolic state involving dramatic alterations in the hormonal or cytokine environments (increases in estrogen, progesterone, prolactin, cortisol, human chorionic gonadotropin, placental growth hormone and human placental lactogen, TNF-alpha, resistin, leptin, and a decrease in adiponectin) as well as an increasing burden of fuel utilization by the conceptus. Metabolically, the first trimester is characterized by increased insulin sensitivity and lipogenesis. The second and third trimesters, in contrast, are characterized by insulin resistance and increased lipolysis.
The adipose tissue is considered an active organ, capable of secreting substances such as adipokines, which may play a role in the pathogenesis of insulin resistance. Resistin, leptin, serum and placental levels increase as pregnancy progresses, which is in contrast to levels of adiponectin. These levels correlate with the state of increased insulin resistance that develops in the latter stages of pregnancy.

Figures and Tables

Table 1
Changes of insulin sensitivity and adipokines during pregnancy
kdj-33-77-i001

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