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<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="brief-report"><?properties open_access?><front><journal-meta><journal-id journal-id-type="nlm-ta">J Korean Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">J. Korean Med. Sci</journal-id><journal-id journal-id-type="publisher-id">JKMS</journal-id><journal-title-group><journal-title>Journal of Korean Medical Science</journal-title></journal-title-group><issn pub-type="ppub">1011-8934</issn><issn pub-type="epub">1598-6357</issn><publisher><publisher-name>The Korean Academy of Medical Sciences</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32776724</article-id><article-id pub-id-type="pmc">7416000</article-id><article-id pub-id-type="doi">10.3346/jkms.2020.35.e282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Brief Communication</subject><subj-group subj-group-type="subheading"><subject>Psychiatry &amp; Psychology</subject></subj-group></subj-group></article-categories><title-group><article-title>The Mediating Effect of Depressive Symptoms on the Relationship between Adverse Childhood Experiences and Problematic Internet Use in Children and Adolescents</article-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-7329-8296</contrib-id><name><surname>Seo</surname><given-names>Jiyeong</given-names></name><xref ref-type="aff" rid="A1-jkms-35-e282">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-1479-6962</contrib-id><name><surname>Lee</surname><given-names>Cheol-soon</given-names></name><xref ref-type="aff" rid="A1-jkms-35-e282">1</xref><xref ref-type="aff" rid="A2-jkms-35-e282">2</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-0201-2518</contrib-id><name><surname>Lee</surname><given-names>Young-Ji</given-names></name><xref ref-type="aff" rid="A1-jkms-35-e282">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0003-2918-0546</contrib-id><name><surname>Lee</surname><given-names>Mi-Sun</given-names></name><xref ref-type="aff" rid="A3-jkms-35-e282">3</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-5254-0314</contrib-id><name><surname>Bhang</surname><given-names>Soo-Young</given-names></name><xref ref-type="aff" rid="A4-jkms-35-e282">4</xref></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-3977-3663</contrib-id><name><surname>Lee</surname><given-names>Dongyun</given-names></name><xref ref-type="aff" rid="A1-jkms-35-e282">1</xref><xref ref-type="aff" rid="A2-jkms-35-e282">2</xref></contrib></contrib-group><aff id="A1-jkms-35-e282"><label>1</label>Department of Psychiatry, Gyeongsang National University Changwon Hospital, Changwon, <country>Korea</country>.</aff><aff id="A2-jkms-35-e282"><label>2</label>Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, <country>Korea</country>.</aff><aff id="A3-jkms-35-e282"><label>3</label>Department of Meditation Psychology, Nungin University, Hwaseong, <country>Korea</country>.</aff><aff id="A4-jkms-35-e282"><label>4</label>Department of Psychiatry, Eulji University Hospital, Eulji University School of Medicine, Seoul, <country>Korea</country>.</aff><author-notes><corresp>Address for Correspondence: Soo-Young Bhang, MD, PhD, MPH. Department of Psychiatry, Eulji University Eulji Hospital, Eulji University School of Medicine, 68 Hangeulbiseok-ro, Nowon-gu, Seoul 01830, Korea. <email>dresme@dreamwiz.com</email></corresp><corresp>Address for Correspondence: Dongyun Lee, MD, PhD. Department of Psychiatry, Gyeongsang National University Changwon Hospital, 11 Samjeongja-ro, Seongsan-gu, Changwon 51472, Republic of Korea. <email>yuny0829@gnu.ac.kr</email></corresp></author-notes><pub-date pub-type="epub"><day>31</day><month>7</month><year>2020</year></pub-date><pub-date pub-type="collection"><day>10</day><month>8</month><year>2020</year></pub-date><volume>35</volume><issue>31</issue><elocation-id>e282</elocation-id><history><date date-type="received"><day>07</day><month>2</month><year>2020</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2020</year></date></history><permissions><copyright-statement>&#xA9; 2020 The Korean Academy of Medical Sciences.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>The Korean Academy of Medical Sciences</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc/4.0/">https://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>The purpose of this study was to evaluate the mediating effect of depressive symptoms on the relationship between adverse childhood experiences (ACEs) and problematic internet use. The study participants were 180 students between the ages of 9 and 18 years. Path analysis was performed to measure the relationships among ACEs, depressive symptoms and problematic internet use. ACEs significantly affected depressive symptoms (standardized regression weight, 0.36; <italic>P</italic> &lt; 0.01), and depressive symptoms also affected problematic internet use (standardized regression weight, 0.40; <italic>P</italic> &lt; 0.01). We found that depressive symptoms had a significant mediating effect on the relationship between problematic internet use and ACEs. The management of depressive symptoms would be important to prevent problematic internet use in children and adolescents with ACEs.</p></abstract><abstract abstract-type="graphical"><title>Graphical Abstract</title><p><graphic xlink:href="jkms-35-e282-abf001.jpg" position="float" orientation="portrait"/></p></abstract><kwd-group kwd-group-type="author"><kwd>Depression</kwd><kwd>Childhood Adversity</kwd><kwd>Problematic Internet Use</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution>Ministry of Health and Welfare</institution><institution-id institution-id-type="CrossRef">https://doi.org/10.13039/501100003625</institution-id></institution-wrap></funding-source><award-id>HM15C1058</award-id></award-group></funding-group></article-meta></front><body><p>Adverse childhood experiences (ACEs) have generally included adversities such as childhood abuse, neglect, and an upbringing in a dysfunctional household.<xref rid="B1-jkms-35-e282" ref-type="bibr">1</xref> ACEs are associated with high-risk health behaviors and may increase the risk of mental illness, including depression and substance addiction, in young adulthood.<xref rid="B2-jkms-35-e282" ref-type="bibr">2</xref><xref rid="B3-jkms-35-e282" ref-type="bibr">3</xref><xref rid="B4-jkms-35-e282" ref-type="bibr">4</xref> Traumatic experiences during childhood can also be associated with psychopathology, including problematic internet use, which has been related to an individual's inability to control his or her use of the internet. Adolescents with ACEs who had experienced inadequate parenting and were raised in insecure home environments are at high risk of emotional dysregulation and may exhibit addictive behaviors such as excessive use of the Internet as self-medication for negative emotional problems.<xref rid="B5-jkms-35-e282" ref-type="bibr">5</xref><xref rid="B6-jkms-35-e282" ref-type="bibr">6</xref> Problematic internet use has been noted as an important psychosocial concern because it has been reported to affect not only psychopathology, such as hyperactivity and depression, but also physical health and poor academic performance.<xref rid="B7-jkms-35-e282" ref-type="bibr">7</xref> In children and adolescents, ACEs, depression, and problematic internet use may appear in sequence or at the same time, but few studies have identified the relationships among these factors. In the systematic review of the relationship between problematic smartphone use and psychopathology, the relationship between problematic smartphone use and depression was bidirectional.<xref rid="B8-jkms-35-e282" ref-type="bibr">8</xref> People with depression were likely to engage in problematic smartphone use because they excessively use their smartphones to cope with negative emotions.<xref rid="B9-jkms-35-e282" ref-type="bibr">9</xref> The individual relationships between ACEs, depressive mood, and problematic internet use have been reported in previous studies, however, there are few studies examining the role of depressive mood in the relationship between ACEs and problematic internet use. We hypothesize that depressive symptoms mediate the relationship between ACEs and problematic internet use. The purpose of this study was to investigate whether depressive symptoms mediate the relationship between problematic internet use and ACEs in children and adolescents.</p><p>From March to October 2017, we surveyed 3,937 students attending schools in Seoul, Korea, who were smartphone users. We used the data from a survey administered as part of a regional mental health project to screen for Internet and smartphone addiction. This study was conducted with adolescents in elementary (from grade 4), middle or high school in Seoul. Researchers provided self-reported questionnaires to the supervisor of the school, and the students whose parents permitted their participating in the survey completed the questionnaires in school. Among these students, one hundred eighty students were considered to be at high risk for problematic internet use and were enrolled with the permission of their parents. Individuals were categorized into the high-risk group if they satisfied any of the following criteria: 1) scores on the Internet Gaming Use-Elicited Symptom Screen (IGUESS)<xref rid="B10-jkms-35-e282" ref-type="bibr">10</xref> &#x2265; 10; 2) smartphone addiction proneness scale scores<xref rid="B11-jkms-35-e282" ref-type="bibr">11</xref> &#x2265; 23; 3) daily internet use &#x2265; 3 hr/wk (elementary school) or &#x2265; 4 hr/wk (middle school and high school); and 4) internet gambling experience or online payments &#x2265; 80 dollars/year.</p><p>The questionnaire used to assess ACEs consisted of 10 questions associated with physical, sexual, or verbal abuse, familial conflicts and psychiatric history.<xref rid="B12-jkms-35-e282" ref-type="bibr">12</xref> The Children's Depression Inventory (CDI) has a total of 27 items and was used to assess depressive symptoms in children 8&#x2013;13 years of age.<xref rid="B13-jkms-35-e282" ref-type="bibr">13</xref> In the Korean validity study, there were no significant differences according to sex, age, or grade, and this version was found to be a useful tool in screening for depression (Cronbach's &#x3B1; = 0.88).<xref rid="B14-jkms-35-e282" ref-type="bibr">14</xref> IGUESS was used as a tool to assess problematic internet use.<xref rid="B10-jkms-35-e282" ref-type="bibr">10</xref> This tool was developed in Korea based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition content to identify obstacles related to Internet game use at community and primary health care centers. The IGUESS included the following 9 items: preoccupation with internet games, withdrawal symptoms, tolerance, unsuccessful attempts to control, loss of interest, continued excessive use, lies regarding the amount of internet gaming, use of internet games to escape negative feeling, and lost opportunities in relationships, work, and education. The responses are divided into four categories: one point is scored for not at all, two for occasionally, three for frequently and four for always. The reliability and validity of this tool have been confirmed (Cronbach's &#x3B1; = 0.94).<xref rid="B10-jkms-35-e282" ref-type="bibr">10</xref> The smartphone addiction proneness scale was developed by the National Information Society agency in Korea. This is a self-reported scale for evaluating smartphone addiction in adolescents. Cronbach's &#x3B1; was 0.880.<xref rid="B11-jkms-35-e282" ref-type="bibr">11</xref> The self-reported questionnaires were used to survey daily internet use duration and internet gambling experience. All self-reported questionnaires were directly completed by the participants.</p><p>The data were statistically analyzed to define the sociodemographic characteristics of the subjects, and Pearson correlation analysis and A path analysis was performed to measure the relationships among ACEs, depressive symptoms and problematic internet use. A P value of 0.05 was set to indicate statistical significance. The model fit of the path analysis was evaluated by calculating the &#x3C7;2 value (CMIN), root mean square error of approximation (RMSEA), and comparative fit index (CFI). The smaller the value of the CMIN is, the better the fit of the model. The RMSEA is acceptable if it is 0.08 or lower, and the CFI is judged to be acceptable if it is 0.09 or higher. The statistical analysis was performed using SPSS for Windows, version 21.0 (SPSS Inc., Chicago, IL, USA) and AMOS 19.0 (SPSS Inc.).</p><p>A total of 180 students (95 boys, 85 girls) aged 9&#x2013;18 years (mean, 12.72 &#xB1; 1.76) participated, including 134 elementary school students (74.4%), 35 middle school students (19.4%) and 11 high school students (6.1%). In the results of Pearson correlation analyses (<xref rid="T1-jkms-35-e282" ref-type="table">Table 1</xref>), there were significant correlations among ACEs, the CDI score and the IGUESS score and between ACEs and the CDI score (<italic>r</italic> = 0.34, <italic>P</italic> &lt; 0.01), ACEs and the IGUESS score (<italic>r</italic> = 0.27, <italic>P</italic> &lt; 0.01), and the CDI and IGUESS scores (0.44, <italic>P</italic> &lt; 0.01). In the linear regression analysis between ACEs and IGUESS, in the absence of the CDI, ACEs significantly affected IGUESS scores (standardized regression weight, 0.27; <italic>P</italic> &lt; 0.01). After the CDI score was added to this model as a mediator, the direct effect of ACEs on the IGUESS score was not significant. Accordingly, a significant mediating effect was found for depressive symptoms on the relationship between problematic internet use and ACEs (<xref ref-type="fig" rid="F1-jkms-35-e282">Fig. 1</xref>). Regarding the indirect effect, ACEs significantly affected the CDI score (standardized regression weight, 0.36; <italic>P</italic> &lt; 0.01), and the CDI score also affected the IGUESS score (standardized regression weight, 0.40; <italic>P</italic> &lt; 0.01). The model fit was appropriate, and the indexes of model validation were as follows: CMIN, 0.01; RMSEA, 0.01; and CFI &gt; 0.9.</p><p>The purpose of this study was to evaluate the mediating effect of depressive symptoms on ACEs and problematic internet use. The main results of this study were as follows: there was a significant association between only two variables, ACEs and IGUESS scores; however, in the path analysis results that included CDI scores as a mediator between ACEs and IGUESS scores, the indirect effect of the CDI scores was statistically significant, and the association between ACEs and IGUESS was not significant. This analysis indicated that depressive symptoms had a significant mediating effect on the relationship between ACEs and problematic internet use. Although few studies have found relationships among depression, problematic internet use and ACEs, previous studies have described associations between internet addiction and several mental health problems, of which depression is the most frequently reported to be associated with internet addiction among adolescents.<xref rid="B15-jkms-35-e282" ref-type="bibr">15</xref><xref rid="B16-jkms-35-e282" ref-type="bibr">16</xref> These previous results suggested that the relationship between Internet addiction and depression may not necessarily be linear but may rather adopt a bidirectional pattern, resulting in a vicious cycle. Another study found that the effect of Internet addiction on adolescent depression is mediated by negative life events.<xref rid="B17-jkms-35-e282" ref-type="bibr">17</xref> In regard to the relationship between traumatic experiences and internet addiction, traumatic memories may increase the risk of problematic internet use via the mediating effect of alexithymia.<xref rid="B18-jkms-35-e282" ref-type="bibr">18</xref> Previous findings support the existence of the associations among depression, problematic internet use and ACEs that were found in this study. ACEs have been reported to be risk factors for diverse psychiatric diseases, such as depression and anxiety disorders.<xref rid="B8-jkms-35-e282" ref-type="bibr">8</xref> Excessive usage of the internet is a strategy for coping with negative emotions in adolescents experiencing stress. Adolescents alleviate negative emotions by communicating via the Internet, and this effect reinforces excessive use of the Internet among adolescents.<xref rid="B9-jkms-35-e282" ref-type="bibr">9</xref> At the same time, excessive Internet use interferes with physical and mental health behaviors in adolescents, causing mental illnesses such as depression.<xref rid="B8-jkms-35-e282" ref-type="bibr">8</xref><xref rid="B19-jkms-35-e282" ref-type="bibr">19</xref> In this study, adolescents with more ACEs were more likely to engage in problematic internet use. Considering the results of previous studies, there could be diverse relationships among ACEs, depression and problematic internet use. This study found that depression is a mediator of the relationship between ACEs and problematic Internet use.</p><p>There are several limitations of this study. First, we used a simple questionnaire to measure depressive symptoms and symptoms of problematic internet use. Therefore, the interpretation of the results is limited. Second, the cross-sectional characteristics of the survey limit the testing of causal paths. Third, the subjects did not have a balanced age distribution in this study. Fourth, there could be other variables that mediate the relationship between ACEs and IGUESS scores, for example, age, sex, socioeconomic status, parental marital status, past psychiatric history, and comorbid psychiatric diseases of the participants and their parents. However, we only considered the CDI score as a mediator in this study. Therefore, future studies should be conducted using specific measurements, structured interviews, and prospective data.</p><p>Despite these limitations, the results of this study could help improve our understanding of the relationships among ACEs, problematic internet use and depressive symptoms. Additionally, it can be assumed that the treatment of depressive symptoms may represent an effective target of interventions to prevent problematic internet use in adolescents with ACEs.</p><sec sec-type="other1"><title>Ethics Statement</title><p>Consent for participation was obtained from the subjects' parents. This study was approved by the Institutional Review Board (IRB) of Eulji University Hospital (IRB No. EMCS 2018-06-014).</p></sec></body><back><fn-group><fn fn-type="supported-by"><p><bold>Funding:</bold> This study was supported by a grant from the Korea Mental Health Technology R&amp;D Project, Ministry of Health &amp; Welfare, Republic of Korea (HM15C1058).</p></fn><fn fn-type="COI-statement"><p><bold>Disclosure:</bold> The authors have no potential conflicts of interest to disclose.</p></fn><fn fn-type="con"><p><bold>Author Contributions:</bold>
<list list-type="simple"><list-item><p><bold>Conceptualization:</bold> Lee CS.</p></list-item><list-item><p><bold>Data curation:</bold> Lee MS.</p></list-item><list-item><p><bold>Formal analysis:</bold> Lee D, Lee CS.</p></list-item><list-item><p><bold>Investigation:</bold> Lee YJ.</p></list-item><list-item><p><bold>Methodology:</bold> Bhang SY.</p></list-item><list-item><p><bold>Software:</bold> Lee CS.</p></list-item><list-item><p><bold>Validation:</bold> Lee CS.</p></list-item><list-item><p><bold>Writing - original draft:</bold> Seo J.</p></list-item><list-item><p><bold>Writing - review &amp; editing:</bold> Bhang SY, Lee D.</p></list-item></list>
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The values shown are standardized regression coefficients. Model fit: CMIN = 0.01, RMSEA = 0.01, and CFI &gt; 0.9.</title><p>CMIN = &#x3C7;<sup>2</sup> value, RMSEA = root mean square error of approximation, CFI = comparative fit index, CDI = Children's Depression Inventory, ACEs = adverse childhood experiences, IGUESS = Internet Gaming Use-Elicited Symptom Screen.</p><p><sup>*</sup><italic>P</italic> &lt; 0.01.</p></caption><graphic xlink:href="jkms-35-e282-g001"/></fig><table-wrap id="T1-jkms-35-e282" orientation="portrait" position="float"><label>Table 1</label><caption><title>Pearson's correlation analysis of depressive symptoms, problematic internet use and ACEs</title></caption><alternatives><graphic xlink:href="jkms-35-e282-i001"/><table frame="hsides" rules="rows"><col width="25%" span="1"/><col width="25%" span="1"/><col width="25%" span="1"/><col width="25%" span="1"/><thead><tr><th valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">Variables</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">CDI</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">ACEs</th><th valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(211,212,235)">IGUESS</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">CDI</td><td valign="top" align="center" rowspan="1" colspan="1">1.00</td><td valign="top" align="center" rowspan="1" colspan="1"/><td valign="top" align="center" rowspan="1" colspan="1"/></tr><tr><td valign="top" align="left" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">ACEs</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">0.34<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)">1.00</td><td valign="top" align="center" rowspan="1" colspan="1" style="background-color:rgb(224,224,241)"/></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">IGUESS</td><td valign="top" align="center" rowspan="1" colspan="1">0.44<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">0.27<sup>*</sup></td><td valign="top" align="center" rowspan="1" colspan="1">1.00</td></tr></tbody></table></alternatives><table-wrap-foot><p>The above values represent correlation coefficients.</p><p>CDI = Children's Depression Inventory, ACE = adverse childhood experience, IGUESS = Internet Gaming Use-Elicited Symptom Screen.</p><p><sup>*</sup><italic>P</italic> &lt; 0.01.</p></table-wrap-foot></table-wrap></floats-group></article>
