IntroductionUltrasonography is most extensively used for preoperative imaging as part of the diagnosis of oral and maxillofacial lesions.1 In recent years, shear wave elastography has been shown to be an effective technique for the objective and quantitative diagnosis of cervical lymph node metastases of oral carcinoma.23
Intraoral ultrasonography has been used to assess features of tongue cancer, including the border, size, location, depth, vascularity, and histological findings of the mass.45 Strain elastography (performed together with intraoral ultrasonography) is relatively new to sonographic imaging, and the use of intraoral strain elastography for tongue cancer has been recently reported in the literature.67
Computed tomography (CT),89 magnetic resonance imaging (MRI),10 and ultrasonography11 can be useful for the preoperative evaluation of palatal lesions. However, to the best of our knowledge, intraoral strain elastography of palatal lesions has not been extensively described in the literature. This report describes 2 clinical cases in which strain elastography was used to assess palatal tumors in conjunction with intraoral ultrasonography, CT, and MRI.
Case ReportCase 1A 54-year-old woman was referred to our hospital with a chief concern of swelling on the right palate that had developed over 6 months. The patient underwent intraoral strain elastography with a linear 17-MHz transducer (Aplio 300; Canon Medical Systems, Otawara, Japan), CT with a 16-detector CT scanner (Aquilion TSX-101A; Canon Medical Systems, Otawara, Japan), and MRI with a 1.5-T magnetic resonance unit (EXCELART Vantage MRT-2003; Canon Medical Systems) at our university hospital in accordance with the institutional protocol.712
On ultrasonography, the tumor showed a clear boundary, hypoechoic echogenicity, homogeneous internal architecture, and no vascular signals (Figs. 1A and B). The strain values of the normal tissue and the tumor were 0.556% and 0.000%, respectively (Figs. 1C and D). CT showed a mass (Figs. 2A and B), and contrast-enhanced CT showed an enhancing mass (Figs. 2C and D). Coronal and sagittal bone-tissue algorithm CT showed no osteolytic lesion, but did not show perineural spread (Figs. 2E and F). On MRI, a coronal T1-weighted image revealed homogeneous low-signal intensity (Fig. 3A), a T2-weighted image showed heterogeneous high-signal intensity (Fig. 3B), and a post-contrast T1-weighted image showed an enhancing mass (Fig. 3C).
Regarding the cut surface of the tumor (Fig. 4A) and the low-magnification view (Fig. 4B; ×1 magnification; scale bar, 5 mm) of the surgical specimen, a thin, discrete fibrous capsule was observed. Furthermore, epithelioid, spindle, and plasmacytoid-neoplastic myoepithelial cells were observed (Fig. 4C; ×40 magnification; scale bar, 50 µm). The histopathological diagnosis was myoepithelioma.
Case 2A 70-year-old woman was referred to our hospital with a chief concern of swelling on the right palate that had developed over 3 months. The patient underwent ultrasonography, CT, and MRI at our university hospital in accordance with the institutional protocol.
On ultrasonography, the tumor showed an unclear boundary, isoechoic echogenicity, homogeneous internal architecture, and vascular signals (Figs. 5A and B). The strain values of the normal tissue and the tumor were 1.077% and 0.000%, respectively (Figs. 5C and D). CT showed a mass (Figs. 6A and B), and contrast-enhanced CT showed an enhancing mass (Figs. 6C and D). Coronal and sagittal bone-tissue algorithm CT images showed an osteolytic lesion and perineural spread (Figs. 6E and F). On MRI, a coronal T1-weighted image revealed homogeneous low-signal intensity (Fig. 7A), a T2-weighted image showed heterogeneous high-signal intensity (Fig. 7B), and a post-contrast T1-weighted image showed an enhancing mass (Fig. 7C).
Regarding the coronal segment of the right maxillary first molar (Fig. 8A, real view) and the low-magnification view (Fig. 8B; ×1 magnification; scale bar, 5 mm) of the surgical specimen, the tumor showed aggressive bone destruction and extension into the maxillary sinus (*) and nasal cavity (★). Furthermore, cribriform and tubular patterns were observed (Fig. 8C; ×40 magnification; scale bar, 50 µm). The histopathological diagnosis was adenoid cystic carcinoma.
DiscussionThis report describes 2 clinical cases in which strain elastography was used to assess palatal tumors in conjunction with intraoral ultrasonography, CT, and MRI.
Regarding the imaging of palatal lesions, Kurabayashi et al.8 showed that on CT, malignant tumors of the minor salivary glands of the palate were very likely to display aggressive bone destruction, extension into the pterygopalatine fossa, and/or calcification. Ju et al.9 indicated that older patients with palatal tumors and intact mucosa should be considered for adenoid cystic carcinoma when CT shows relatively high palatine foramen enlargement. Yuan et al.10 showed that a combination of conventional MRI and apparent diffusion coefficient score could facilitate the differentiation of malignant from benign palatal lesions. Ishii et al.11 indicated that intraoral ultrasonography of palatal tumors could be used to determine the localization and condition of tumors via close echogram analysis. The present report described 2 clinical cases (including both malignant and benign tumors) in which strain elastography was utilized to assess palatal tumors in conjunction with intraoral ultrasonography, CT, and MRI. We conclude that intraoral strain elastography may be useful for evaluating palatal lesions.
Inspection and palpation are frequently used for the clinical diagnosis of oral and maxillofacial lesions. Ogura et al.13141516 devised an instrument for measuring the consistency of oral cancer, quantitatively evaluated this consistency, and additionally evaluated the consistency of early invasive carcinoma of the oral cavity to enable the early detection of oral carcinoma. Along similar lines, we posit that using intraoral strain elastography in the assessment of palatal lesions may be helpful for the clinical diagnosis of early carcinoma of the palate.
The main limitation of our study is the possibility that patients may experience a few adverse effects from ultrasonography, including deep tissue heating, acoustic cavitation, and acoustic streaming. Ter Haar17 described the existing laboratory and epidemiological evidence regarding the safety of diagnostic ultrasound.
In summary, we described 2 clinical cases in which strain elastography was used to assess palatal tumors along with intraoral ultrasonography, CT, and MRI. We conclude that intraoral strain elastography may be useful for evaluating palatal lesions.